Capable

Capable

Scientist / Senior Scientist, RNA Therapeutics

San Francisco · Senior

Sponsorship not specified$135k-$180kDetected 25 days ago
PharmacologyqPCRMass SpectrometryProtein AnalysisWestern BlottingAnimal StudiesMentoring

> stay_score

odds of building a lasting career here

33Unrated
Cap-exempt (no lottery)0
Sponsors this role0
Entry-level history0
PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70

No strong sponsorship signal in the public record yet. In the full product we resolve the exact legal entity and show its filing history with a confidence score — treat as unverified until then.

Lottery odds assume a STEM candidate.

Personalize to your clock →

> community_outcomes

No reports yet — be the first to help the next applicant.

About the role

  • We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
  • Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.

Responsibilities

  • Design ASOs, siRNAs, splice-switching oligos, gapmers, steric-blocking oligos, and other RNA-targeting molecules against key targets.
  • Develop core sequence strategies for RNase H knockdown, splice modulation, translation blocking, miRNA inhibition, transcript stabilization, or other RNA-level mechanisms.
  • Build and refine design rules around potency, specificity, GC content, secondary structure, isoform selectivity, SNPs, conservation, off-target risk, immune activation, and manufacturability.
  • Build the full ASO program package: target rationale, sequence set, chemistry plan, assay strategy, QC data, in vitro and in vivo results, failure modes, and next-step logic.
  • Able to reason from target biology to oligo design to assay readout: choosing the right transcript, mechanism, chemistry, and knowing what data will validate your efforts.
  • Comfortable designing and interpreting assays that validate RNA therapeutics, including target knockdown or splice correction, transcript and protein-level readouts, pathway modulation, cell viability, immune activation, and in vivo tissue target engagement.
  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.

Requirements

  • Hands-on experience with RNA therapeutics, ASOs, siRNA, splice-switching oligos, RNA biology, nucleic acid chemistry, pharmacology, or closely related work.
  • Experience with qPCR, ddPCR, RNA-seq, western blot, ELISA, reporter assays, splice assays, cytokine panels, or tissue analysis is helpful.
  • You do not need to have experience with every item on this list
  • we value deep expertise in some areas and a willingness to learn in others.

Compensation

  • $135,000-$180,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.

Benefits

  • $135,000-$180,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.
  • $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
  • You will also have access to HSA, FSA, and 401K plans.
  • We read every referral carefully, and if your referral joins Capable, we'll send you a thank-you bonus.

Company info

  • ABOUT THE ROLE We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

Visa & Work Authorization

  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.
Apply directly at Capable →Create a free account for alerts like thisView Capable immigration profile

This listing is sourced directly from Capable's careers page and normalized into a canonical job model.