Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company
Executive Director, Toxicology
Boston, MA · Director · Full-time
Sponsorship not specified$270k-$300kDetected 6 days ago
PharmacologyFDA RegulatoryResearchAnimal StudiesLeadershipCommunicationMentoringPublic Speaking
About the role
- Work Location The Executive Director, Toxicology role is based in the US, with occasional travel.
- We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
- Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.
Responsibilities
- Lead and mentor a team of toxicologists and technical/operational staff, fostering scientific excellence and professional growth
- Lead nonclinical sub‑teams as an integrated development head, providing cross‑functional oversight across Toxicology, DMPK, Bioanalytical Sciences, and Clinical Pharmacology to ensure aligned, program‑ready nonclinical strategies.
- Design, oversee, and interpret GLP, non‑GLP, investigative, and in vitro toxicology studies
- Develop safety strategies for new targets, lead optimization programs, and platform technologies
- Author and critically review toxicology sections of regulatory documents (e.g., pre‑IND, IND, IBs)
- Partner with biology, DMPK, pathology, pharmacology, clinical, and regulatory colleagues to drive integrated decision‑making
- Support product defense and regulatory submissions through robust scientific rationale
- Build scalable toxicology capabilities to support a growing and diverse pipeline
Requirements
- 18+ years of experience in pharmaceutical or biotechnology R&D with a strong track record in nonclinical and regulatory toxicology
- Deep expertise supporting small‑molecule programs across discovery, IND‑enabling, and early clinical development
- Strong working knowledge of national and international GLP guidelines
- Strong ability to integrate complex nonclinical datasets across toxicology, pathology, DMPK, and pharmacology to inform development decisions
- Experience overseeing outsourced toxicology and safety pharmacology studies and managing CRO partnerships
- PhD in Toxicology, Pharmacology, Pathology, DVM, or related discipline; board certification (e.g., DABT, ERT) preferred
- Proven ability to function as an upward‑facing nonclinical leader and generalist, with the credibility and judgment to represent PDTs at governance, engage confidently with regulatory agencies, and serve as a trusted development partner to senior leadership.
- Demonstrated experience defining and executing nonclinical safety strategies to support diverse pipelines and novel biology
- Proven leadership experience building, managing, and mentoring toxicology teams within a collaborative, matrixed environment
- Extensive experience preparing and reviewing nonclinical sections of global regulatory submissions and engaging with health authorities (FDA, EMA)
- Excellent communication and influencing skills, with the ability to partner effectively across Early Development, Research, and Regulatory functions in a fast‑paced environment
Nice to have
- PhD in Toxicology, Pharmacology, Pathology, DVM, or related discipline
- board certification (e.g., DABT, ERT) preferred
Compensation
- The annual base salary range for this position is $270,000.00 to $300,000.00.
- Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge and location.
- In addition to base pay, this role is eligible for a discretionary annual bonus.
Company info
- Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants.
- We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
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