Alumis
Senior/Executive Medical Director, Clinical Development (New Indications)
South San Francisco · Director
Sponsorship not specified$20k-$30kDetected 2 days ago
Business DevelopmentClinical TrialsPharmacologyFDA RegulatoryResearchExperimental DesignAnimal StudiesLeadershipCommunicationCollaborationBiostatisticsRegulatory Affairs
About the role
- Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.
- This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.
- Remote candidates will be considered on a case-by-case basis.
Responsibilities
- Lead the design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 in neurology (e.g., neurodegenerative diseases, movement disorders) and for additional pipeline molecules in inflammatory and immunologic indications
- Develop and refine clinical development plans, including study synopses, protocols, and integrated development strategies for new indications
- Partner with Clinical Operations, Biostatistics, and Regulatory Affairs to ensure efficient study execution and high-quality data generation
- Prepare and review clinical sections of regulatory submissions, including IND amendments, briefing documents, and meeting packages
- Work closely with Translational Sciences, Biomarker, and Pharmacology teams to integrate biomarker strategies into clinical study designs
- Provide clinical expertise to support business development activities, including evaluation of potential partnerships or in-licensing opportunities
- Contribute to building Alumis's clinical development capabilities as the organization grows
Requirements
- Track record of successful regulatory interactions (FDA, EMA) and experience preparing IND/CTA submissions
- Strong scientific acumen with the ability to critically evaluate preclinical and clinical data to inform development strategy
- Excellent leadership, communication, and interpersonal skills with the ability to influence cross-functional teams in a matrixed environment
- Strategic mindset with demonstrated ability to balance scientific rigor with business objectives
- Travel required (approximately 20-30%) to support investigator meetings, scientific conferences, regulatory interactions, and site visits.
Nice to have
- Experience with indication expansion or lifecycle management for neurology or immunology assets
- Prior experience at a small or mid-sized biotechnology company
- comfort operating in a fast-paced, resource-conscious environment
- Established relationships with KOLs in neurology
- relationships in rheumatology, dermatology, or other inflammatory disease areas also valued
- Familiarity with regulatory pathways for expedited development (Breakthrough Therapy, Fast Track)
- Opportunity to shape the clinical development strategy for a best-in-class TYK2 inhibitor portfolio
- High-visibility leadership role with direct interaction with executive leadership and the CMO
Compensation
- The salary range for this position is $300,000 USD to $400,000 USD annually.
Benefits
- Competitive compensation package including base salary, annual bonus, and equity participation
- Comprehensive benefits including health, dental, vision, 401(k), and generous PTO
- Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.
- Health insurance premiums paid at 90% for employee, 80% for dependents
- $100 monthly cell phone stipend
- Unlimited PTO for Exempt employees
- Collaborate with Translational Medicine and Research teams to evaluate and prioritize new indication opportunities based on scientific rationale, competitive landscape, and unmet medical need
- Serve as the Medical Monitor for assigned Phase 1 and 2 studies, ensuring patient safety and scientific integrity
- Oversee medical aspects of study conduct, including safety surveillance, protocol amendments, and data review
- Lead interactions with Data Safety Monitoring Boards (DSMBs) and provide medical input for safety analyses
- Build and maintain relationships with investigators, academic collaborators, and the broader medical community
- Collaborate with Commercial and Medical Affairs teams on disease landscape assessments and indication prioritization
Company info
- This salary range is an estimate, and the actual salary may vary based on the Company's compensation practices.
- We are a hard-working, collaborative team on a mission to transform patient's lives-- and we aspire to elevate, challenge and nurture one another along the way.
Equal opportunity
- Alumis Inc. is an equal opportunity employer.
This listing is sourced directly from Alumis's careers page and normalized into a canonical job model.