Gordian Biotechnology

Senior Computational Biologist

South San Francisco, CA · Senior

Sponsorship not specifiedDetected 22 days ago

PythonAWSData AnalysisBioinformaticsCRISPRNGSResearchAnimal StudiesAnimal ModelsCommunicationCollaborationProblem Solving

About the role

Your mission as a Computational Biologist at Gordian is to measure the impact of single-cell perturbations on transcriptomic state, and use those signals to predict changes in physiological state under therapeutic conditions.
You'll focus on cardio-renal-metabolic indications and relevant tissues (heart, kidney, adipose, liver, etc.), partnering closely with disease-area experts and experimental teams to translate screen results into clear, testable biological hypotheses.
Over time, you'll help establish and iterate on selection criteria for validation that improves screening efficiency and translatability across programs.

applying our technology to create comprehensive atlases of therapeutic targets across multiple diseases, partnering for financial and intellectual support, and translating these insights into new medicines.

PhD in Bioinformatics, Computational Biology, or a related quantitative field.
Strong statistical foundations and judgment around controls, confounders, and interpretability, plus the ability to communicate results clearly through honest, high-signal visualizations and concise summaries.
Additional valuable skills if you have them Experience with pooled perturbation and screening data (for example, CRISPR or barcode-driven screens) and single-cell perturbation analysis methods.
Prior work in cardio-renal-metabolic biology and relevant tissues (heart, kidney, adipose, liver), either directly or through close collaboration with disease experts.
Experience with preclinical models for validation with functional readouts (e.g. in human explants, organoids, etc)

Our mission is audacious, and the path will be full of both challenges and excitement.
Gordian Biotechnology is a therapeutics company whose mission is to cure age-related disease and wake up every morning more capable than the day before.
We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to rapidly prioritize targets and interventions with a clear path toward development (more info on our website ).
We are running this discovery engine to ensure an abundance of therapeutic hypotheses can be tested for complex diseases, eventually mapping out the effects of every druggable target across many diseases, and advancing programs both internally and through collaborations with external partners.
Our culture is a source of great pride; it represents both who we are and who we wish to be.

This listing is sourced directly from Gordian Biotechnology's careers page and normalized into a canonical job model.