Ginkgo Bioworks
Computational Synthetic Chemist
Boston, Massachusetts · Senior
Sponsorship not specified$115k-$165kDetected 59 days ago
PythonMachine LearningPandasA/B TestingResearchCollaborationMentoring
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odds of building a lasting career here
54Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70
Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
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About the role
- Computational route planning, retrosynthesis, condition prediction, and automated or high-throughput experimentation resources will be standard working tools-not occasional aids.
- You will consume model output, judge when it is useful, correct it when it is not, and feed outcomes back into the planning and prediction workflows.
- The ideal candidate is an accomplished bench chemist who is also fluent in computer-aided synthesis planning (CASP), reaction-prediction tools, and reaction data.
Responsibilities
- Design, select, and execute practical multi-step routes to novel drug-like singleton compounds and focused sets under real constraints on time, materials, building blocks, and available resources.
- Apply a broad synthetic-organic chemistry toolkit and own purification and characterization through delivery of high-quality, well-characterized compounds on schedule.
- Use chemical structure and reaction representations and building-block catalogs to constrain plans to realistic starting materials, and design or interpret HTE and other reaction-optimization experiments.
- Design chemistry for automation and parallel execution where useful, while recognizing when a route genuinely requires manual bench work.
- Collaborate with chemists, computational scientists, and software engineers to define useful tools, make go/no-go heuristics explicit, and mentor junior chemists.
Requirements
- or an M.S. with 6 years, or a B.S. with 9 years, of relevant experience.
- You know the difference between useful guidance and an output that is not reliable enough to use.
- You are intellectually curious and impatient with the status quo, with a passion for establishing and advancing state-of-the-art chemistry workflows in practical production settings.
Nice to have
- Python scripting with tools such as RDKit, pandas, or Jupyter for manipulating compound sets, parsing analytical output, or prototyping analyses.
- Experience running chemistry on robotic platforms, liquid handlers, flow systems, or other automated resources.
- Industrial HTE or nanoscale reaction-screening experience.
- Prior work in a CRO, fee-for-service, or similarly schedule-driven environment.
- Experience with ELN/LIMS configuration or reaction-data model definition.
- Experience scaling a validated route from milligram to multi-gram quantities.
- Experience with inline or process monitoring such as ReactIR, benchtop NMR, or online LC-MS.
- Experience mentoring or supervising junior chemists.
Skills
- Feed practical outcomes and corrected synthetic judgment back into planning, prediction, and cheminformatics workflows.
Compensation
- Receive competitive compensation, generous equity in a public company, and a robust benefits package.
Benefits
- critically evaluate proposed routes and predictions and explain when they are implausible, impractical, or outside reliable coverage.
Company info
- Our mission is to make biology easier to engineer.
- We are hiring a Senior Engineer I, Synthetic Chemistry to design and execute multi-step syntheses of novel drug-like molecules, including singleton analogs and small focused sets that cannot be made in plate format.
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This listing is sourced directly from Ginkgo Bioworks's careers page and normalized into a canonical job model.