Raven
Raven StealthCo - Principal Scientist, Analytical Chemistry
Boston, MA · Principal
Sponsorship not specified$160k-$190kDetected 7 days ago
Clinical TrialsResearchMass SpectrometryAnimal StudiesAnimal ModelsLeadershipAdaptabilityOrganizational Skills
About the role
- This individual will help define and execute the strategy to analyze oligonucleotides and conjugates in an efficient and timely manner.
- As a lab-based role, this person will assist in the implementation and use of scientific and analytical equipment to yield high-quality oligonucleotide and oligonucleotide-conjugate materials.
- Specific responsibilities for the Principal Scientist, Analytical Chemistry include:
Responsibilities
- They have brought hundreds of therapeutics into development, managed hospital systems, optimized clinical trials and navigated payor and regulatory systems to deliver patient impact - and they are ready to work with you.
- Define and implement reproducible analytical protocols to characterize oligonucleotides for biological evaluation in our targeted delivery platform
- Develop and implement QC methods to determine purity, composition, and concentration of oligonucleotides and conjugates using a toolbox of analytical methods (HPLC, MS, (bio)analytical assays, etc.)
- Develop and implement analytical methods (e.g., MS) to determine drug-to-conjugate ratios of antibody-oligonucleotide conjugates
- Develop and implement analytical methods to determine in vitro stability (e.g., serum stability) of oligonucleotides and conjugates
- Assist in internal lab build, procuring and utilizing analytical equipment to characterize oligonucleotides and antibody/peptide-oligonucleotide conjugates
- Assist conjugation scientists in developing methods (SEC, IEX, etc.) to purify oligonucleotide conjugates
Requirements
- PhD. in chemistry or related discipline with 6+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry
- or BS/MS with 10+ years
- Imperative that this individual be an effective communicator and proven team-player, with the ability to operate independently in a laboratory setting
- The Principal Scientist, Analytical Chemistry must be highly organized, thoughtful, and bring sound judgement and technical decision-making abilities.
- PhD. in chemistry or related discipline with 6+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry; or BS/MS with 10+ years
Nice to have
- Experience in (bio)analytical assays to determine pharmacokinetic, distribution, and PD profiles of oligonucleotide therapeutics is a plus
Compensation
- The base salary range reflects our good faith estimate at the time of posting.
Company info
- At a personal level, we are seeking an individual who is highly collaborative, intellectually curious, driven, trustworthy, humble, and who brings an adaptable and flexible working style.
- The company is creating a culture of highly engaged colleagues who put the team and the science above the self and operate with a sense of urgency.
- From an educational perspective, we are seeking an individual with a Ph.D. and/or BS/MS in a relevant discipline such as chemistry or analytical sciences.
- This person will be based on-site at the company's headquarters in Cambridge, MA.
This listing is sourced directly from Raven's careers page and normalized into a canonical job model.