Ginkgo Bioworks
Engineer III, ADME
Boston, Massachusetts · Mid · Full-time
Sponsorship not specified$90k-$140kDetected 16 days ago
PythonData AnalysisData VisualizationPharmacologyResearchMass SpectrometryCommunicationCollaboration
About the role
- Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe's growing challenges in health, energy, food, materials, and more.
- The base salary range for this role is $90,000 - $140,000.
Responsibilities
- Execute, optimize, and help validate a range of in vitro ADME assays such as solubility, MDCK permeability, plasma protein binding, microsomal stability, hepatocyte stability, and CYP inhibition/induction.
- Perform sample preparation and analytical workflows for high-throughput ADME studies, including LC-MS/MS, high-throughput mass spectrometry, and related mass spectrometry-based readouts.
- Support transfer of manual methods into higher-throughput and automation-enabled workflows, working with liquid handlers and related instrumentation where appropriate.
- Present results clearly to medicinal chemistry and cross-functional project teams to support compound progression and decision-making.
- Partner with computational and data teams to ensure data outputs are structured, QC'd, and analysis-ready.
- Maintain clear, accurate laboratory records, SOPs, and electronic notebooks.
- Work closely with ADME, automation, analytical, and data colleagues to scope work, communicate progress, and deliver high-quality data on timeline.
Requirements
- Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or a related field with 3+ years of relevant industry experience
- or M.S. with 5+ years
- or B.S. with 7+ years of relevant hands-on industry experience.
- Hands-on experience with in vitro ADME assays and associated experimental workflows in a drug discovery or related setting.
- Practical experience with LC-MS/MS, high-throughput mass spectrometry, acoustic MS, or similar analytical approaches used to support high-throughput assay readouts.
- Experience working with laboratory automation or semi-automated workflows in a research environment.
Nice to have
- Familiarity with drug metabolism pathways, DMPK concepts, and the use of metabolomics or related analytical approaches to contextualize compound behavior and assay results.
- Experience with data visualization or scripting tools such as Python or R.
- Familiarity with ELN, LIMS, or related electronic laboratory data systems.
- Experience working in a CRO environment or collaborating with external assay providers.
- What Success Looks Like
- ADME assays are executed reliably, with strong documentation, clean QC, and reproducible outputs.
- Analytical, HT-mass spec, and assay workflows become more robust, scalable, and transferable over time, with growing integration of metabolomics-informed readouts where useful.
- Project teams receive timely, high-quality ADME data that informs compound decisions.
Compensation
- The base salary range for this role is $90,000 - $140,000.
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