Flagshippioneeringinc
Senior Scientist, Biology
Cambridge, MA USA · Senior
Sponsorship not specified$126k-$160kDetected 6 days ago
Data AnalysisStatisticsComplianceRecruitingClinical TrialsPharmacologyqPCRFlow CytometryMicroscopyMolecular BiologyScientific WritingResearchExperimental DesignProtein AnalysisWestern BlottingAnimal StudiesLeadershipCommunicationPublic Speaking
About the role
- We are seeking a highly motivated and experienced Senior Scientist to join our research team.
- The successful candidate will possess deep expertise in cell isolation and sorting, in vivo/ in vitro mouse studies, gene-silencing technologies (siRNA), flow cytometry and advanced microscopy techniques.
- This individual will play a key role in designing, executing, and interpreting preclinical studies to therapeutic programs.
Responsibilities
- Design, execute, and analyze complex in vitro and ex vivo experiments to support discovery and preclinical research programs.
- Lead and perform multi-parameter flow cytometry assays, including panel design, optimization, troubleshooting, and data interpretation.
- Perform and optimize cell isolation and cell sorting (e.g., FACS, MACS) from various tissues and biological samples.
- Develop and apply siRNA-based approaches for target validation, pathway interrogation, and mechanistic studies.
- Design and perform microscopy-based experiments, including fluorescence, confocal, live-cell, and high-content imaging, and analyze imaging datasets.
- Utilize complementary molecular and cellular biology techniques to support target validation and mechanism-of-action studies.
- Design, analyze, and interpret cell profiling experiments using flow cytometry, imaging, and molecular approaches.
- Generate technical reports, presentations, study summaries, and scientific documentation to support program advancement.
- Collaborate effectively with internal teams, CROs, academic collaborators, and external partners.
- For Senior Scientist and Principal Scientist levels, provide scientific leadership, contribute to research strategy, and lead cross-functional initiatives.
Requirements
- Ph.D. in Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Biomedical Sciences, or a related field with 6+ years of relevant experience for Senior Scientist roles
- 8+ years of industry experience and demonstrated scientific leadership for Principal Scientist roles.
- Alternatively, an M.S. degree with substantial relevant industry experience.
- Hands-on experience with cell isolation techniques, including tissue dissociation and magnetic bead-based separation.
- Extensive experience with mouse models and in vitro experimental techniques.
- Hands-on experience with microscopy platforms, including fluorescence, confocal, live-cell, and high-content imaging systems.
- Ability to work independently and collaboratively in a fast-paced, multidisciplinary environment.
- Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis using FlowJo or equivalent software.
- Demonstrated expertise in siRNA design, delivery, optimization, and functional validation.
- Strong quantitative data analysis, experimental design, and statistical analysis skills.
- Excellent communication, presentation, and scientific writing skills.
Nice to have
- Experience in translational research, drug discovery, or preclinical therapeutic development.
- Experience in biotechnology or pharmaceutical industry settings.
- Experience with cell profiling, phenotyping, and functional assays using primary mouse and human cells, as well as established cell lines.
- Experience with single-cell and/or spatial biology technologies, including scRNA-seq, CITE-seq, or spatial transcriptomics.
- Experience managing CROs, external collaborators, and cross-functional project teams.
- Proficiency with additional molecular and cellular biology techniques, including:
- Western blotting
- ELISA and multiplex cytokine assays
Compensation
- FL106 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
Benefits
- FL106 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
- Compensation and benefits information is based on FL106's good faith estimate as of the date of publication and may be modified in the future.
Visa & Work Authorization
- California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information.
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