Output

Output

Head of Discovery

New York HQ 🗽

Sponsorship not specifiedDetected 47 days ago
PythonData AnalysisPharmacologyBioinformaticsAnimal StudiesLeadership

About the role

  • Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates.
  • Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible.
  • We're already generating therapies that traditional approaches cannot reach.

Responsibilities

  • You will identify and evaluate therapeutic targets, building the scientific rationale for which programs to pursue and why
  • You will manage CRO partnerships for candidate synthesis and biological testing, designing experiments that validate or refine drug design hypotheses
  • The hardest problems in both AI and biology are being solved here, and there is room for you to own one.
  • You own the scientific strategy behind Output's drug discovery programs.
  • Healthy feedback focused environment to help you strive - leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you
  • You own your day-to-day management.
  • Leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you
  • Our goal is to create a workplace that is fun, engaging, rewarding and fulfilling.
  • You have hands-on experience advancing drug discovery programs through pipeline stages: target selection, hit identification, hit-to-lead, and lead optimization
  • You can build and defend a scientific rationale, communicate across disciplines, and make decisions under uncertainty

Requirements

  • You have demonstrated experience evaluating drug candidates and making scientific go/no-go decisions on real programs
  • You have strong scientific judgment across target biology, disease mechanisms, and therapeutic modalities
  • You have experience with AI-driven drug discovery or computational drug design tools
  • You have experience managing CRO relationships for synthesis and biological testing
  • You have experience across multiple therapeutic areas or modalities, including small molecules and peptides
  • You have a track record of advancing compounds into preclinical or clinical development
  • You have programming skills in Python, with the ability to work with data analysis tools and model outputs hands-on
  • You have publications at top-tier venues or relevant drug discovery and medicinal chemistry journals

Compensation

  • Competitive salary and equity in a growing, well-funded startup

Benefits

  • Competitive salary and equity in a growing, well-funded startup
  • Excellent medical, dental, and vision coverage

Company info

  • We foster a culture of ownership.
  • We are assembling a team of individuals who are passionate and take pride in their contributions.
  • We value practicality and results-oriented thinking.
  • We are committed to making a tangible impact on the lives of patients and the broader community.
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This listing is sourced directly from Output's careers page and normalized into a canonical job model.