Vertex Pharmaceuticals
Immunology Senior Research Scientist - Spatial Transcriptomics
Seattle, WA · Senior
Sponsorship not specified$124k-$186kDetected 12 days ago
PythonData AnalysisRecruitingPharmacologyBioinformaticsMolecular BiologyResearchExperimental DesignCommunicationCollaborationProblem SolvingPublic Speaking
About the role
- This role will be instrumental in driving mechanistic insights into disease biology, tissue microenvironments, and therapeutic response through spatial profiling of gene expression in tissue context.
- Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
- Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Responsibilities
- Lead the design, execution, and optimization of spatial transcriptomics studies to address key biological questions in disease-relevant tissues and model systems
- Lead efforts to characterize tissue architecture, cellular microenvironments, cell-cell interactions, and spatial organization of biological processes
- Generate and interpret high-quality spatial data to derive biological insights that support disease biology, target biology, mechanism of action, and biomarker strategies
- Develop, validate, and implement robust workflows for sample preparation, assay execution, quality control, and data review
- Drive adoption of best practices and contribute to establishing robust spatial biology workflows and standards across the team
- Partner closely with cross-functional teams across disease biology, pharmacology, translational medicine, biomarker sciences, bioinformatics, and clinical development to inform study design, data interpretation, and program strategy
- Mentor junior scientists and help build a collaborative, high-performing team environment
Requirements
- PhD in Immunology, Cell Biology, Molecular Biology, Biology, Biomedical Sciences, or related discipline with 2+ years of relevant experience
- Master's degree with 6+ years of relevant experience
Nice to have
- Hands-on experience with one or more spatial transcriptomics platforms (e.g., sequencing-based or imaging-based such as 10x Genomics Visium, Nanostring CosMx or similar technologies)
- Experience with histology, immunofluorescence, image analysis, and multiplexed tissue profiling
- Experience supporting drug discovery, translational research, or clinical biomarker development, ideally in immunology or inflammation
- Familiarity with single-cell RNA-seq analysis and integration of multi-omics datasets
- Experience in immunology and inflammation disease areas
- Knowledge of spatial proteomics or broader tissue-based profiling approaches
Skills
- Deep expertise in spatial transcriptomics and tissue-based molecular profiling
- Strong understanding of transcriptomics, RNA biology, tissue architecture, and cellular heterogeneity
- Experience with fresh frozen and FFPE tissue processing, tissue quality assessment, and assay optimization
- Familiarity with one or more spatial biology platforms, including sequencing-based and imaging-based technologies
- Experience integrating spatial data with single-cell, proteomic, imaging, and histologic datasets
- Strong experimental rigor, problem-solving ability, and attention to data quality and reproducibility
- Excellent communication skills and ability to work effectively in a matrixed, multidisciplinary environment
- Education and Experience:
- Master's degree with 6+ years of relevant experience; or
- Bachelor's degree with 8+ years of relevant experience
Compensation
- $124,200 - $186,400
- The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting.
- This role is eligible for an annual bonus and annual equity awards.
- Some roles may also be eligible for overtime pay, in accordance with federal and state requirements.
- Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
Benefits
- This role is eligible for an annual bonus and annual equity awards.
Company info
- The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
- Company Information
- Vertex is a global biotechnology company that invests in scientific innovation.
- Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.
- Vertex is an E-Verify Employer in the United States.
- Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
- Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
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