Amgen
Principal Scientist - Cardiometabolic Disorders
US - California - Thousand Oaks · Principal
Sponsorship not specifiedDetected 71 days ago
PharmacologyBioinformaticsMolecular BiologyResearchAnimal StudiesLeadershipCommunicationMentoringPublic Speaking
Stay score
odds of building a lasting career here
38Risky
Cap-exempt (no lottery)0
Sponsors this role85
Entry-level history0
PERM / green-card track0
Lottery odds40
Fits your clock70
Thin sponsorship signal and lottery-bound. A low-probability bet with your clock running. Prioritize cap-exempt roles and proven entry-level sponsors first.
Lottery odds assume a STEM candidate.
Personalize to your clock →Employer immigration record
from this employer's Department of Labor filings
Green-card filing pattern in this occupation
Context, not a finding about this posting: of this employer's 101 green-card filings in this occupation, 100% were for a worker who already held the job.
Green-card follow-through: 92%
Of 75 labor certifications old enough to have been used, 6 expired without the employer filing the next step. Median time from filing to decision: 486 days.100% of their filings were for a worker who already held the job.Only certifications past the 180-day window are counted — recent ones cannot have expired yet.
Files H-1B transfers
17 transfer filings in the last year, covering 17 workers. Median labor-condition decision: 7 days. An employer that already files transfers is one that can take over an existing H-1B.
Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
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About the role
- Join Amgen's Mission of Serving Patients
- At Amgen, if you feel like you're part of something bigger, it's because you are.
- Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases.
Responsibilities
- Develop and implement translational pharmacology strategies to evaluate novel therapeutic mechanisms and optimize candidate molecules.
- Design, oversee, and interpret in vitro and in vivo pharmacology studies, including efficacy, mechanism-of-action, PK/PD, and biomarker investigations.
- Lead cross-functional scientific discussions and influence program direction through rigorous data interpretation and critical thinking.
- Identify and implement innovative pharmacology approaches and emerging technologies to advance GPCR-targeted drug discovery.
- Mentor and develop scientists while fostering scientific excellence, innovation, and collaboration.
- You will lead the design and execution of translational pharmacology strategies to advance innovative therapeutic candidates from target validation through candidate selection.
Requirements
- Doctorate degree PhD
- MD [and relevant post-doc where applicable] and 2 years of experience in pharmaceutical, biotechnology, or related drug discovery research
- Master's degree and 5 years of experience in pharmaceutical, biotechnology, or related drug discovery research
- Bachelor's degree and 7 years of experience in pharmaceutical, biotechnology, or related drug discovery research
Nice to have
- PhD in Pharmacology, Physiology, Endocrinology, Cell Biology, Molecular Biology, or a related scientific discipline with 5+ years of experience in pharmaceutical or biotechnology drug discovery.
- Extensive expertise in GPCR biology, pharmacology, and signaling, with a deep understanding of receptor pharmacology, signal transduction, and mechanism-of-action studies.
- Strong expertise in pharmacological characterization of peptide, antibody, multispecific, or other biologic therapeutics.
- Demonstrated ability to integrate in vitro pharmacology, in vivo efficacy, PK/PD, biomarker, and human biology data to guide scientific decisions and advance discovery programs.
- Experience mentoring scientists and leading cross-functional collaborations in a fast-paced drug discovery environment.
- Excellent written and verbal communication skills with a strong track record of publications, presentations, and scientific contributions.
- Demonstrated creativity, scientific curiosity, and a passion for discovering transformative therapies for patients with obesity and related metabolic diseases.
- Award-winning time-off plans
Compensation
- 140,123.35USD -189,578.65 USD
Company info
- Career Category Scientific Job Description Join Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are.
- If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team.
- What we expect of you We are all different, yet we all use our unique contributions to serve patients.
- We are all different, yet we all use our unique contributions to serve patients. The Principal Scientist we seek is an accomplished scientific leader with these qualifications.
Equal opportunity
- Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
- Please contact us to request accommodation.
- We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Visa & Work Authorization
- Sponsorship for this role is not guaranteed.
This listing is sourced directly from Amgen's careers page and normalized into a canonical job model.