Capable

Capable

Senior Scientist, Peptide Chemistry (Night Shift)

San Francisco · Senior

Sponsorship not specified$200k-$260kDetected 25 days ago
RF EngineeringMass SpectrometryAnimal StudiesMentoring

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odds of building a lasting career here

37Unrated
Cap-exempt (no lottery)0
Sponsors this role0
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

No strong sponsorship signal in the public record yet. In the full product we resolve the exact legal entity and show its filing history with a confidence score — treat as unverified until then.

Lottery odds assume a STEM candidate.

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About the role

  • We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
  • Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.

Responsibilities

  • Lead and execute synthesis across peptide, peptide-adjacent, and small-molecule programs, including route planning, reaction setup, solid-phase or solution-phase synthesis, purification, analytical characterization, and sample preparation.
  • Run and optimize microwave-assisted solid-phase peptide synthesis where relevant, including resin loading, coupling/deprotection cycles, cleavage, crude analysis, purification, and final compound QC.
  • Prepare compounds for in vitro and in vivo testing, maintain rigorous experimental records, and communicate overnight synthesis results, issues, timelines, and risks clearly to the day team.
  • Contribute to next-round compound design by sharing chemistry insight on synthetic feasibility, purity, yield, stability, solubility, and structure-property relationships.
  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.

Requirements

  • You are specifically looking for or open to a senior night-shift lab role.
  • You are comfortable working overnight hours, operating independently, making sound technical decisions, and handing off clean, well-documented work to the day team.
  • You have 5+ years of hands-on industry experience in medicinal, organic, peptide, or related chemistry, with strong experimental judgment, deep troubleshooting ability, and a high bar for execution.
  • Peptide experience is helpful, but not required.
  • You are excited to learn or deepen solid-phase synthesis while bringing strong synthetic chemistry fundamentals.
  • You are proactive and reliable when issues arise.

Compensation

  • $200,000-$260,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.

Benefits

  • $200,000-$260,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.
  • $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
  • You will also have access to HSA, FSA, and 401K plans.
  • We read every referral carefully, and if your referral joins Capable, we'll send you a thank-you bonus.

Company info

  • ABOUT THE ROLE We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

Visa & Work Authorization

  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.
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This listing is sourced directly from Capable's careers page and normalized into a canonical job model.