Twenty Twenty Therapeutics

Twenty Twenty Therapeutics

Staff Product Manager

New York, NY · Staff+ · Full-time

No sponsorshipDetected 1 day ago
A/B TestingCybersecurityProduct ManagementProduct StrategyAgileLeadership

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odds of building a lasting career here

37Risky
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds40
Fits your clock70

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About the role

  • ABOUT THE COMPANY America is under sustained cyber attack.
  • Our adversaries infiltrate our networks, steal our IP, and degrade the digital infrastructure that modern life runs on.
  • They've learned-correctly-that those attacks rarely produce consequences.

Responsibilities

  • Lead the product from initial discovery through MVP definition, launch, iteration, and scale.
  • Develop a deep understanding of user workflows, incentives, constraints, and trust requirements.
  • Design experiences that support both human users and automated participants.
  • Partner closely with a team of approximately three to five engineers to define scope, sequence delivery, and make sound technical and product tradeoffs.
  • Lead or actively support sprint planning, backlog prioritization, acceptance criteria, and product reviews.
  • Create alignment across engineering, users, and leadership on what to build, why it matters, and what comes next.
  • Some positions may also require eligibility to obtain and maintain a U.S. Government security clearance.

Requirements

  • You are motivated by understanding how users actually operate and translating those insights into intuitive, effective product experiences.
  • You are comfortable conducting user interviews, identifying patterns, and making decisions when the available signal is incomplete.
  • You know how to define a focused MVP, launch it quickly, and use real-world feedback to determine what comes next.
  • You are comfortable working closely with a small engineering team and taking an active role in shaping requirements, sequencing work, and driving execution.
  • You are at your best in small, high-trust teams with high standards and meaningful ownership.
  • You are comfortable in high-speed, high-stakes environments and take the initiative to solve problems even when they fall outside your direct job responsibilities.
  • You have demonstrated experience taking a product or major capability from 0→1.
  • You have experience as a Product Manager with meaningful ownership across both product strategy and execution.
  • You have strong user interview, discovery, and synthesis skills.
  • You have defined and launched MVPs, using early feedback and product signals to guide iteration.

Nice to have

  • You have experience leading product development sprints and maintaining strong acceptance criteria.
  • You have built marketplace, platform, matching, or multi-sided network products.
  • You have experience designing products that require trust, transparency, identity, reputation, or access controls.
  • You have built products serving multiple participant types with different workflows and incentives.
  • You have built or managed AI-driven or agentic products.
  • You have experience designing products used by both humans and automated systems.
  • You have worked in government, defense, intelligence, cybersecurity, or similarly mission-driven environments.
  • You might work with products that use operational data and behavioral signals to improve matching and decision-making.

Benefits

  • Medical, dental, and vision plan options.
  • Life / AD&D, disability coverage options.
  • Paid parental leave for eligible full-time employees.
  • Paid holidays and flexible PTO.
  • HSA/FSA options, dependent care FSA.
  • Own the product vision, strategy, and execution.
  • Benefits vary by location, role, and eligibility.

Company info

  • America is under sustained cyber attack.
  • Twenty was founded to change that, by making our adversaries think twice before they attack us.
  • Our vision is American and allied primacy in cyberspace-a future where they cannot contest us, deterrence is assured, and the free world remains secure.
  • Founded in 2024, Twenty Technologies (www.twenty.io http://www.twenty.io) industrializes offensive cyber operations for the U.S. and its allies.
  • Headquartered in Arlington, Virginia, Twenty has raised $168M from Khosla Ventures, Accel, Caffeinated Capital, Friends & Family Capital, Point72 Ventures, General Catalyst, and In-Q-Tel.
  • This is a 0→1 product role for someone who can move from early user discovery through MVP launch and iteration.
  • You will work closely with a small team of engineers, users, and executive leadership to define the marketplace experience, establish its foundational workflows, and determine how matching, trust, and participation should work at scale.
  • The problems are complex, the requirements will evolve, and there is no established playbook.
  • Success will require strong product judgment, deep user empathy, and the ability to move fluidly between long-term strategy and hands-on execution.

Equal opportunity

  • equal opportunity employer.
  • If you need a reasonable accommodation during the hiring process, let us know and we will work with you.

Visa & Work Authorization

  • Government security clearance
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This listing is sourced directly from Twenty Twenty Therapeutics's careers page and normalized into a canonical job model.