Glyphic Biotechnologies
Staff / Senior Scientist, Bioconjugation Chemistry
Berkeley, CA · Staff+ · Full-time
Sponsorship not specified$123k-$188kDetected 92 days ago
ConfluenceIntellectual PropertyExperimental DesignMass SpectrometryAdaptability
About the role
- This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.
- This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.
- We celebrate diversity and are committed to creating an inclusive environment for all employees.
Responsibilities
- Partner with sample prep and assay development to screen and select conjugation chemistries for peptides and oligonucleotides that enable single molecule protein sequencing
- Design bioconjugation workflows using NHS-ester chemistry, maleimides, isothiocyanate chemistry, and click chemistry (CuAAC, SPAAC, IEDDA)
- Develop labeling strategies based on Edman Chemistry
- Develop and apply selective C-terminal and N-terminal conjugation chemistries
- Develop site-specific labeling strategies for amino acid sidechains (Cys, Lys, Arg, Tyr, Trp, His, Asp/Glu) on native peptides. Screen protecting groups to enhance amino acid signal in the protein sequencing assay
- Collaborate and document:
- Work cross-functionally with sample preparation, assay integration, and reagent manufacturing teams to troubleshoot conjugation failures and optimize workflows
- Maintain rigorous experimental documentation in Confluence and laboratory notebooks; author and maintain SOPs for new conjugation methods
- Industry experience in bioconjugation chemistry, with demonstrated ability to independently design, develop, and troubleshoot conjugation workflows
- Track record developing novel blocking groups and conducting SAR studies to optimize blocking group performance and selectivity
Requirements
- MS/PhD with 8+/6+ years of experience (for Staff Scientist)
- MS/PhD with 6+/4+ years of experience (for Senior Scientist)
- Experience with site-specific amino acid sidechain chemistry beyond maleimide chemistry (e.g. Cys, Lys, Arg, Tyr, Trp, Asp/Glu) for application in multistep workflows
- Proficiency in analytical characterization: HPLC method development, LC-MS/MS for conjugate analysis, UV/Vis, and CE
Nice to have
- Hands-on experience with solid-phase peptide synthesis (SPPS), including protecting group strategies beyond standard Fmoc/Boc and selective on-resin modifications
- Experience with peptide C-terminal chemistry manipulation methods: thioester formation, native chemical ligation, or photoredox/iridium-catalyzed C-terminal labeling
- Familiarity with oligonucleotide chemistry and oligo-conjugation techniques (ITC, phosphoramidite modifications, click coupling to nucleic acids)
- Experience with scalable surface chemistry methods for flow cells or solid-phase supports
- Prior experience in an early-stage biotech or tools/diagnostics company
- Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
- Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
- Treats obstacles as problems to be creatively solved, not reasons something can't be done.
Skills
- Synthesize and purify peptide and oligonucleotide conjugates for assay testing
- Characterize conjugation efficiency, purity, and stability using tools such as HPLC, LC-MS/MS, NMR, CE, UV/Vis, and FTIR
- Learn from a diverse team of world-class scientists and engineers
- Contribute to first-of-their kind technologies, high-impact publications, and patents
Compensation
- Estimated Base Salary $123,000 - $187,575
- This is the pay range for this position that we reasonably expect to pay.
- Individual compensation is based on various factors including, experience, education, skillset, and geographic location.
Benefits
- Employee Stock Option Plan
- 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
- Employer Retirement Contributions to 401(k)
- Generous Paid Time Off
- Paid Maternity and Paternity Leave
- Health & Wellbeing Program
- To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.
Company info
- Collaborative culture where your ideas and expertise are valued
- Direct impact on product development and company direction
Equal opportunity
- We are an Equal Opportunity Employer.
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