Amgen
Scientist / Senior Scientist, Structural Biology
US - California - South San Francisco · Senior
Sponsorship not specifiedDetected 7 hours ago
PythonStructural AnalysisBioinformaticsResearchMentoringPublic Speaking
About the role
- Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases.
- With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year.
- Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.
Responsibilities
- Partner with discovery teams to evaluate samples, define structural biology strategies, and develop fit-for-purpose experimental plans.
- Perform and guide cryo-sample preparation, grid optimization, screening, data collection, image processing, model building, refinement, and structural interpretation.
- Deliver high-quality structural insights that inform mechanism of action, molecular design, and therapeutic decision-making.
- Develop scalable, reproducible CryoEM workflows that improve throughput, robustness, and data quality.
- Collaborate across Structural Biology, Protein Sciences, Therapeutic Discovery, Protein Engineering, Computational Biology, Medicinal Chemistry, Automation, Molecular Characterization, and therapeutic area teams.
- Evaluate and implement emerging technologies-including automation and AI-enabled tools-to improve data collection, analysis, and workflow efficiency.
- Support and/or lead CryoEM platform activities at the South San Francisco site, including operation of the 200 kV Glacios 2 and user support for the 300 kV Titan Krios.
- In this vital role you will help discovery teams tackle challenging mechanistic questions by developing practical structural biology strategies, enabling high-quality structural analysis, and delivering insights that support therapeutic program decisions.
- This position offers a unique opportunity to combine hands-on structural biology with technology innovation in support of biologics and small-molecule drug discovery across multiple therapeutic areas.
Requirements
- Doctorate degree PhD in Structural Biology, Biochemistry, Biophysics, or a related field.
- Master's degree and 3 years of Structural Biology experience
- Bachelor's degree and 5 years of Structural Biology experience
Nice to have
- Experience with X-ray crystallography, MicroED, electron tomography, or integrative structural biology.
- Experience supporting structure-based drug discovery in an industry setting.
- Experience studying membrane proteins, antibodies, multispecifics, GPCRs, or other challenging therapeutic targets.
- Familiarity with automated data collection software such as EPU.
- Experience mentoring scientists or training CryoEM users.
- Record of scientific publications, presentations, or technology innovation.
- Passion for collaborative science and continuous improvement.
- Experience scripting/coding with Python and/or other programming languages is a plus.
Compensation
- 142,518.65USD -192,819.35 USD
Company info
- We are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a researcher with these qualifications.
- We are all different, yet we all use our unique contributions to serve patients.
Equal opportunity
- Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
- Please contact us to request accommodation.
- Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
- We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Visa & Work Authorization
- Sponsorship for this role is not guaranteed.
This listing is sourced directly from Amgen's careers page and normalized into a canonical job model.