Genentech

Genentech

Scientist 3/4, Complex in Vitro Systems

South San Francisco, USA · Senior

Sponsorship not specified$100k-$186kDetected 1 day ago
PCRMicroscopyMolecular BiologyCell CultureResearchExperimental DesignProblem SolvingPublic SpeakingAdaptability

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odds of building a lasting career here

59Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role100
Entry-level history0
PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.

Lottery odds assume a STEM candidate.

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Employer immigration record

from this employer's Department of Labor filings

Green-card filing pattern in this occupation

Context, not a finding about this posting: of this employer's 21 green-card filings in this occupation, 100% were for a worker who already held the job.

Green-card follow-through: 77%

Of 13 labor certifications old enough to have been used, 3 expired without the employer filing the next step. Median time from filing to decision: 487 days.100% of their filings were for a worker who already held the job.Only certifications past the 180-day window are counted — recent ones cannot have expired yet.

Files H-1B transfers

34 transfer filings in the last year, covering 34 workers. Median labor-condition decision: 8 days. An employer that already files transfers is one that can take over an existing H-1B.

Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.

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About the role

  • In this lab-based role, you will provide scientific and technical expertise in stem cell culture, induced pluripotent stem cell (iPSC)-derived systems, 3D cell and tissue models, and complex in vitro platforms.
  • While the role will have an emphasis on ocular applications, candidates with strong general expertise in stem cell biology, iPSC-derived models, organoids, 3D culture systems, or other complex in vitro platforms are encouraged to apply.
  • This position is ideal for an experienced experimental scientist passionate about advancing drug discovery and translational research through innovative stem cell-based and human-relevant in vitro approaches.

Responsibilities

  • Maintain and expand human stem cell and iPSC cultures, including differentiation, maturation, cryopreservation, quality control, and phenotypic characterization.
  • Design and execute experiments to establish the reproducibility, robustness, and biological relevance of complex in vitro models.
  • Develop and apply functional and phenotypic assays using approaches such as cytotoxicity and viability assays, immunofluorescence, confocal and high-content imaging, molecular profiling, and functional readouts.
  • Support the development and application of ocular complex in vitro models, including retinal, RPE, vascular, organoid, and co-culture systems, to address drug discovery and translational questions.
  • Apply rigorous experimental design, troubleshooting, and protocol optimization to establish reproducible and scalable workflows.
  • Collaborate closely with multidisciplinary teams within and outside gRED to align model development and experimental strategies with program needs.
  • Maintain comprehensive electronic documentation in accordance with departmental procedures and contribute to study reports, scientific presentations, and internal or external publications.
  • The Scientist will work closely with cross-functional teams to develop and apply complex in vitro models that address biological and translational questions.

Requirements

  • BS/MS in Stem Cell Biology, Cell Biology, Molecular Biology, Bioengineering, Toxicology, or a related discipline, with relevant research experience in industry or academia.
  • Demonstrated hands-on expertise in mammalian cell culture, with significant experience in human stem cells and/or iPSC culture, differentiation, and characterization.
  • Strong understanding of cell and tissue biology and experience developing assays to evaluate cellular phenotype, viability, differentiation, function, or response to perturbation.
  • Ability to independently execute laboratory studies, analyze and interpret data, and translate experimental findings into clear scientific conclusions.

Nice to have

  • Experience with functional characterization of epithelial or endothelial systems, including barrier, permeability, or related tissue-level assays.
  • Experience with cell engineering, genome editing, automation/high-throughput workflows, or design of experiments (DOE).

Compensation

  • The expected salary range for this position based on the primary location of California is $100,400 to $186,400 for a Scientist 3 and $124,800 to $231,800 for a Scientist 4.

Benefits

  • Relocation benefits are not available for this position.

Equal opportunity

  • equal opportunity employer.
  • If you have a disability and need an accommodation in relation to the online
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This listing is sourced directly from Genentech's careers page and normalized into a canonical job model.