Profluent
Research Associate II - Senior Research Associate II, LNP Formulation & Drug Delivery
Emeryville, California, United States; On-site · Senior
Work authorization required$83k-$119kDetected 30 days ago
Machine LearningSparkData AnalysisProcess ImprovementIntellectual PropertyCRISPRResearchMass SpectrometryAnimal Studies
About the role
- Execute the formulation of LNPs encapsulating diverse gene editing payloads (mRNA, sgRNA) for in vitro validation and in vivo preclinical studies.
- Sponsorship will not be provided now or at any time in the future for this position.
- Hiring Salary Range $83,000 - $119,000 USD
Responsibilities
- Execute the formulation of LNPs encapsulating diverse gene editing payloads (mRNA, sgRNA) for in vitro validation and in vivo preclinical studies. Optimize LNP potency by conducting Design of Experiments (DOE) type of studies
- Implement process development (e.g. mixing optimization, TFF process optimization, buffer optimizations) in preparation for scaled-up production
- Perform routine and advanced LNP analytics, including particle size/polydispersity (e.g., dynamic light scattering), zeta potential, pKa determination, and encapsulation efficiency (e.g., RiboGreen assays)
- Collaborate closely with internal therapeutics translation teams and external CROs to advance multiple programs forward
- Maintain rigorous electronic laboratory records (ELN) and contribute to technical reports, patent applications, and future regulatory filings
- Optimize LNP potency by conducting Design of Experiments (DOE) type of studies
- High-growth opportunity with meaningful impact on the future of protein design
- Practical knowledge of DOE (Design of Experiments) software such as JMP or Design-Expert for systematic formulation screening and optimization
Requirements
- Research Associate II: BS with 2+ years of relevant industry experience.
- Senior Research Associate: MS with 2-4 years
- OR BS with 4-6 years of relevant industry experience
- Proven hands-on experience with LNP production (e.g., microfluidic mixing, T-junction) and purification techniques (TFF, dialysis)
- Hands-on experience in nanoparticle characterization tools and techniques related to nucleic acid quantification
- attention to experimental details and ability to identify subtle deviations and troubleshoot formulation inconsistencies effectively
- Functional proficiency in GraphPad Prism for data analysis, including generating scientific graphs and performing routine statistical tests (e.g., t-tests and ANOVA)
- Excellent verbal and written skills with a demonstrated ability to summarize complex datasets for diverse stakeholders
- Familiarity with automation or robotic platforms for rapid formulation library generation
- Experience with LC-based analysis tools for lipids and RNA (e.g., HPLC/UPLC, UPLC-CAD)
Nice to have
- 4+ years preferred
- Must have at least 2 years of experience working in an industry lab
Compensation
- Hiring Salary Range $83,000 - $119,000 USD
Benefits
- Competitive compensation package with equity participation
- Comprehensive benefits including health/dental/vision insurance
- Generous PTO policy and commitment to work-life balance
Equal opportunity
- equal opportunity employer promoting diversity and inclusion in the workspace.
Visa & Work Authorization
- Applicants must have ongoing work authorization in the United States that does not require employer sponsorship.
- Sponsorship will not be provided now or at any time in the future for this position.
Apply directly at Profluent →Create a free account for alerts like thisView Profluent immigration profile
This listing is sourced directly from Profluent's careers page and normalized into a canonical job model.