Natera
Senior Bioinformatics Scientist
San Carlos, CA · Senior
Stay score
odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$17,042 more — $147,742 — moves this role to Level III and 3 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $147,742 would place this position at wage Level III. That figure is within the posted range, and I'd like to target it. This role classifies under "Biological Scientists, All Other" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Biological Scientists, All Other (19-1029) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
Employer immigration record
from this employer's Department of Labor filings
Green-card follow-through: 87%
Files H-1B transfers
Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
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About the role
- These will be the models that detect cancer in the minimal residual disease (MRD) setting and help inform treatment selection.
- The ideal candidate brings a strong background in algorithm development, genomics, sequencing data processing, and applied machine learning.
- When you join Natera, you'll work hard and grow quickly.
Responsibilities
- Own end-to-end research analyses, from ideation through implementation (scripts and notebooks), troubleshooting, and performance evaluation, including developing new features within existing pipelines.
- Translate between wet-lab experimental design and computational analysis, navigating ambiguity as assay requirements evolve and maintaining rigorous quality control across high-volume sequencing data spanning multiple cohorts, vendors, and clinical protocols.
- Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
Requirements
- Ph.D. in Bioinformatics, Computer Science, Engineering, Biochemistry, or a related field, with a strong focus on cancer epi/genomics with 0-3 years of professional experience.
- Master in Bioinformatics, Computer Science, Engineering, Biochemistry, or a related field, with a strong focus on cancer epi/genomics with 4-6 years of professional experience.
- Knowledge, Skills, and Abilities:
- Strong quantitative reasoning and data analysis skills, with a demonstrated ability to apply them effectively to relevant scientific problems.
- Experience with Python and Linux command-line tools, including writing shell scripts.
- Strong computational and programming skills, including thorough experience with Python statistical packages (NumPy, Matplotlib, Pandas).
- Ability to work on a cross-functional team in a highly collaborative environment, partnering with both computational and experimental scientists.
- Deep theoretical and practical understanding of high-throughput DNA sequence data analysis, including mapping, sequence alignment, and variant calling workflows.
- Demonstrated experience in developing core ML models, including generalized linear models, kernel methods, tree-based algorithms, and neural networks, with a focus on biological data (e.g., DNA sequencing data)
- Experience with Python and Linux command-line tools, including writing shell scripts. Strong computational and programming skills, including thorough experience with Python statistical packages (NumPy, Matplotlib, Pandas).
- Compensation & Total Rewards
- This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.
Skills
- Experience in algorithm development and data analysis, including applying and evaluating statistical methods.
- Familiarity with public databases such as TCGA, COSMIC, or OncoKB.
- Ability to visualize findings and summarize results in oral and written form for both technical and non-technical audiences.
- High scientific rigor, with eagerness to teach and learn new computational methods and biology.
- Annual performance incentive bonus
- Long-term equity awards
- Comprehensive health benefits (medical, dental, vision)
- 401(k) with company match
- Generous paid time off and company holidays
- Additional wellness and work-life benefits
- BBB announcement on job scams
- FBI Cyber Crime resource page
Compensation
- $130,700 - $163,400 USD
- Annual performance incentive bonus
Benefits
- Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
- Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits.
- Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more.
- Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
Company info
- Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
- We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives.
Equal opportunity
- Equal Opportunity Employer.
This listing is sourced directly from Natera's careers page and normalized into a canonical job model.