Prime Medicine
Associate Scientist/Engineer II Technology, Development and Operations - Chemistry
Cambridge, MA · Mid · Full-time
Stay score
odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~30% per draw at Level II). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
The bottom of this range ($80,000) is below the Level I prevailing wage of $114,275. An H-1B cannot be filed below the prevailing wage, so an offer at the floor of this band could not be sponsored as posted.
DOL prevailing wage, 2026-27 wage year · Software Developers (15-1252) · Boston-Cambridge-Newton, MA-NH. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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About the role
- Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients.
- Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung.
- For more information, please visit www.primemedicine.com.
Responsibilities
- Perform routine and non-routine responsibilities for solid-phase chemical synthesis of long guide RNA and downstream purification including chromatography, TFF and lyophilization at different scales using various state-of-the-art laboratory equipment
- Work together with team members to discuss technical and analytical findings and incorporate into the process design for manufacturing implementation
- Maintain various lab instruments such as ÄKTA synthesizers, AKTA purifiers, preparative scale HPLC, TFF skids, etc, in good operational conditions
- Support new technology evaluations with emphasis on product quality, productivity and/or process robustness
Requirements
- BS or MS in biotechnology, engineering, chemistry, biochemistry, or related life science discipline with ideally 3+ years (BS) or 1+ years (MS) of relevant industry experience in biotech/biopharma.
- Experience working in a GMP manufacturing environment, including equipment qualification, investigation and troubleshooting, and operations.
- Working knowledge of statistical software (e.g., JMP) for process analysis, and data visualization
- Highly self-motivated, and driven, with a can-do attitude and the ability to reliably meet and exceed expectations.
Nice to have
- Experience in chemistry process development of complex biomolecules
- experience in oligonucleotide synthesis or downstream purification is a plus
- Fast learner with a proven ability to understand process development unit operations understanding from first principles and operationally, and to set up and run equipment and instrumentation.
- Prior hands-on experience with equipment and unit operations typically used in process development and manufacture of RNA is preferred
Compensation
- $80,000 - $90,000 USD
Company info
- Position Overview We are actively seeking a talented and highly motivated Associate Scientist/Engineer II to join our RNA chemistry team.
- We are actively seeking a talented and highly motivated Associate Scientist/Engineer II to join our RNA chemistry team.
- Conduct hands-on manufacturing of IND-enabling and GLP/GMP RNA guides to support various Prime Editing programs as part of the chemistry team.
Equal opportunity
- Prime Medicine is proud to be an equal opportunity employer.
This listing is sourced directly from Prime Medicine's careers page and normalized into a canonical job model.