Legend Biotech US

Scientist, Solid Tumor CAR-T

Philadelphia, PA · Full-time

No sponsorship$111k-$145kDetected 15 hours ago

PCRqPCRCRISPRFlow CytometryMolecular BiologyResearchAnimal StudiesCollaborationPublic Speaking

About the role

We are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors.
The ideal candidate holds a PhD in Immunology, Immuno-Oncology, or a closely related discipline, with up to 3 years of postdoctoral experience.
You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.

Perform comprehensive phenotypic analysis of T cell differentiation, activation, and memory subsets.
Analyze and interpret data, troubleshooting, maintain detailed experimental records.
panel design, data acquisition (e.g., Attune,Novocyte, Cytek Aurora), and analysis (FlowJo).

Primary human T cell isolation, activation, lentiviral transduction, and expansion is required.
Experience with humanized mouse models for in vivo CAR-T evaluation.
Proficiency in CAR-T cell trafficking studies: IHC/IF of tumor sections, in vivo imaging.
Familiarity with gene editing tools (CRISPR/Cas9) for cell engineering.
Experience with in vitro Organoid cancer model establishment and expansion.
Experience in solid tumor indications (e.g., lung, gastric, or other refractory cancers).
Applicants must be authorized to work in the United States.
If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law.

Design and execute in vitro CAR-T functional assays.
Evaluate CAR-T cell trafficking and tumor infiltration in vivo using flow cytometry and immunohistochemistry.
Handling and engineering human and murine T cells as well as various cancer cells.
Engineering and maintaining various cancer cell lines for model development.

Performance-based bonus and/or equity is available to employees in eligible roles.
Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one.
Please note: These benefits are offered exclusively to permanent full-time employees.
Contractors are not eligible for benefits through Legend Biotech.

This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.

This listing is sourced directly from Legend Biotech US's careers page and normalized into a canonical job model.