Iambic Therapeutics
Director/Senior Director, Medicinal Chemistry
San Diego HQ · Director
Sponsorship not specifiedDetected 98 days ago
Machine LearningA/B TestingClinical TrialsResearchAnimal StudiesLeadershipCommunicationProblem SolvingTime ManagementMentoring
About the role
- Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting.
- This position will be on-site at our San Diego Headquarters.
Responsibilities
- Lead a group of project scientists and drive molecular discovery efforts to deliver development and clinical candidates
- Devise strategies to execute hit ID, identify lead molecules and optimize them for potency, selectivity, and ADME using multivariant SAR analysis and hypothesis driven design principles.
- Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
- Contribute to platform development by collaborating with AI/ML and chemistry automation teams to enhance processes and accelerate the design-make-test (DMT) cycle.
- Proven cross-functional leadership: integrating biology, DMPK/ADME, CADD, and CMC to build and execute strategic project plans.
- We seek an accomplished and creative medicinal chemistry leader with a proven track record of success in advancing drug discovery programs, setting scientific strategy, and leading cross-functional teams to deliver impact.
Requirements
- Ph.D. in Organic Chemistry with 15+ years of Pharma/bio-tech drug discovery experience (portfolio of programs from hit/lead to development candidate) or MS/BS with 20+ years of experience
- Expertise in modern synthetic organic chemistry, evidenced by high-quality publications and patents.
- Practical experience and working knowledge of target protein degradation and associated modalities (molecular glues, PROTACS)
- Track record of program leadership advancing compounds through preclinical development (candidate nomination, IND-enabling interfaces, CRO oversight).
- Experience mentoring or leading junior chemists
Benefits
- We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team.
Company info
- We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
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