Medra
Scientist, Cell Biology & Antibody Engineering
San Francisco
Sponsorship not specifiedDetected 83 days ago
RoboticsFlow CytometryCell CultureResearchMass Spectrometry
About the role
- Run biophysical characterization on antibody candidates - including SPR and BLI for affinity and kinetics, and epitope binning - and interpret results to inform go/no-go
Responsibilities
- Design, execute, and interpret antibody screening and characterization campaigns across the full funnel - from high-throughput primary hit triage through orthogonal confirmation
- Develop and run cell-based binding and functional assays using flow cytometry to characterize antibodies, VHHs, and other binder formats
- Maintain and engineer mammalian cell lines (e.g., Expi293, ExpiCHO, HEK293, CHO) and establish cell-based characterization and functional assays
- You will work closely with scientists and roboticists to develop and validate assays and bring them into routine execution on our platform.
- Partner with roboticists and software engineers to translate manual assay workflows into reliable, high-throughput autonomous protocols on the Medra platform
- Maintain rigorous experimental records in electronic lab notebooks (ELN) and communicate results clearly to internal and external stakeholders
- Deep hands-on expertise in flow cytometry, including high-throughput formats and panel design
Requirements
- Ph.D. in cell biology, immunology, biochemistry, or a related discipline with 2+ years of industry experience, or a B.S./M.S. with 6+ years of deep, hands-on industry experience.
- Strong background in mammalian cell culture and sterile technique, with a track record of maintaining healthy, reproducible cell lines for assay work
Nice to have
- Experience screening antibodies against challenging target classes (e.g., GPCRs, ion channels, multi-pass membrane proteins)
- Experience with alternative binder formats - VHHs, bispecifics, Fc-fusions, ADCs, or non-Ig scaffolds
- Hands-on experience with lab automation and liquid handling platforms
- Experience expressing and purifying antibodies in HEK293/CHO systems
Skills
- Comfort establishing target-overexpressing cell lines and evaluating/implementing new assay technologies
Benefits
- Significant equity ownership
- Medical insurance and dental Insurance
- We offer relocation benefits for applicants who need to relocate.
- (OPTIONAL) Bonus Points If You Have:
Company info
- We're a team of passionate, mission-driven engineers and scientists from companies like Tesla, Amazon, SpaceX, and Neuralink. We're collaborative and love moving fast, both with our product and on team trips skiing or go-karting!
- As a team, we love nerding out about engineering and robotics - plus other topics like race cars or cooking. We like learning new things and then sharing our new knowledge with each other.
- Our team is opinionated and straightforward. We don't mind intense discussions about design tradeoffs. If we have arguments or miscommunication, we resolve conflicts quickly and empathetically.
- At Medra, our mission is to use AI, robotics, and biology to accelerate life science research, with the ultimate goal of eradicating disease.
- We have been quietly building the foundational layers of our
- We are looking for a Scientist to join our team and to develop and execute antibody screening and characterization on the Medra Physical AI platform.
Visa & Work Authorization
- l conditions), sexual orientation, gender identity, gender expression, age, marital status, military or veteran status, citizenship, or other characteristics protected by state, federal or local law or our other policies
This listing is sourced directly from Medra's careers page and normalized into a canonical job model.