Epicrispr Biotechnologies

Epicrispr Biotechnologies

Research Associate II/Senior Research Associate, Process Development

South San Francisco, California, United States · Senior

Sponsorship not specified$80k-$108kDetected 85 days ago
Data AnalysisInventory ManagementPCRCRISPRFlow CytometryCell CultureResearchAnimal StudiesProblem SolvingCritical ThinkingPublic Speaking

About the role

  • Our company is based on the science of our founder, Stanley Qi, one of the original CRISPR co-inventors who then furthered the technology so that DNA does not need to be cut to accomplish gene regulation.
  • Instead, we regulate the epigenome to suppress and activate multiple genes simultaneously.

Responsibilities

  • Conduct studies to develop representative scale-down models for manufacturing processes
  • Support upstream production campaigns to meet preclinical material demands on schedule and within quality expectations
  • Assist in generating and analyzing data sets to support process development reports, tech transfer documents, and internal presentations
  • Perform and analyze dPCR and flow cytometry experiments
  • Maintain thorough, accurate, and timely documentation of experimental methods, data, and results
  • Support general lab operations including equipment maintenance, reagent and consumable inventory management, vendor coordination, and sample tracking
  • Collaborate cross-functionally with Research, Analytical Development, and Manufacturing teams
  • This individual will contribute to the development and optimization of our in-house AAV platform, support preclinical vector supply, and play an active role in day-to-day lab operations.
  • This role will support the development of scalable and robust processes to advance our gene regulation platform.

Requirements

  • B.S. degree in Cell Biology, Biochemistry, Biology, or a related discipline with 4+ years of relevant industry experience (or M.S. with 2+ years)
  • Hands-on experience with mammalian cell culture (adherent and suspension), aseptic technique, and transient transfection
  • Demonstrated proficiency in benchtop bioreactor AAV production (inoculation through clarification)
  • Familiarity with AAV or viral vector production
  • Experience with analytical methods such as PCR/dPCR and flow cytometry
  • Solid data analysis skills with ability to interpret complex results, communicate findings, and recommend next steps
  • Exceptional attention to detail with proven excellence in experimental documentation
  • The ideal candidate is a hands-on experimentalist with strong experience in mammalian cell culture and viral vector production, who thrives in a fast-paced, collaborative startup environment.
  • Familiarity with statistical design and analysis, including Design of Experiments (DoE), is preferred
  • Strong critical thinking and creative problem-solving skills
  • Self-motivated, proactive and takes initiative when managing multiple priorities
  • Collaborative team player who communicates openly and effectively within department and cross-functionally

Nice to have

  • Prior experience in a startup environment is a plus

Compensation

  • The salary range for this position is $80,000 to $108,000 USD annually.
  • Epicrispr Biotechnologies is an early-stage biotechnology company developing a novel technology platform that can provide safe and persistent control of targeted gene regulation.
  • Our proprietary platform represents an entirely new class of therapeutics that can be leveraged to treat severe disease across numerous therapeutic areas, including complex diseases impacted by multiple genes.
  • This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.
  • This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.

Company info

  • We are further evolving the platform and leveraging its strengths to address unmet medical needs.
  • We are looking for exceptional team members who want an active role in building a rapidly growing biotech.
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