Genentech

Genentech

Senior Manager Digital Manufacturing & Shopfloor Innovation, CVRM

Holly Springs, USA · Senior

Sponsorship not specifiedDetected 1 day ago
Data AnalysisStakeholder ManagementERPRoboticsMechanical DesignAR/VRGMPFDA RegulatoryLeadershipCommunicationMentoringBIMSCADA

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odds of building a lasting career here

42Risky
Cap-exempt (no lottery)0
Sponsors this role100
Entry-level history0
PERM / green-card track0
Lottery odds40
Fits your clock70

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Employer immigration record

from this employer's Department of Labor filings

Green-card follow-through: 77%

Of 13 labor certifications old enough to have been used, 3 expired without the employer filing the next step. Median time from filing to decision: 487 days.100% of their filings were for a worker who already held the job.Only certifications past the 180-day window are counted — recent ones cannot have expired yet.

Files H-1B transfers

34 transfer filings in the last year, covering 34 workers. Median labor-condition decision: 8 days. An employer that already files transfers is one that can take over an existing H-1B.

Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.

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About the role

  • The Senior Manager of Digital Manufacturing & Shopfloor Innovation is the site's operational and technical leader responsible for transforming physical factory operations into a seamlessly connected, digital shopfloor.
  • This is a hands-on people leadership role combining technical execution, program management, adoption leadership, and team development.
  • Your mission is to bridge the gap between complex digital platforms and daily shopfloor operations, ensuring operators have real-time data visibility, seamless connectivity to plant systems, and the insights they need to make better decisions.

Responsibilities

  • Own the site Digital Twin roadmap, ensuring seamless integration between physical assets, real-time operational data, and predictive simulation models that drive shopfloor decision-making
  • Own the site Digital Twin demand and backlog, translating business needs (especially operator-facing use cases) into clearly defined requirements with owners, identifying relevant KPIs, data requirements, and acceptance criteria
  • Hands-on technical work: Identify simulation requirements and collaboratively work with 3rd-party simulation expert teams to develop and enhance models
  • validate new simulations for fidelity and accuracy
  • Define and manage the site budget for digital twin software enhancements, licenses, infrastructure upgrades, and vendor support

Requirements

  • 8+ years in pharmaceutical manufacturing, smart factory initiatives, Manufacturing Execution Systems (MES), or shopfloor digitization within pharmaceutical or biotech manufacturing
  • Proven hands-on experience with Digital Twin architectures, demonstrating ability to understand simulation requirements, validate models for accuracy, and drive operational insights
  • Practical experience with AR/VR enterprise platforms (e.g., PTC Vuforia, HoloLens, or equivalent implementations)
  • Hands-on experience with eBR systems, electronic batch record workflows, and paperless manufacturing execution
  • Familiarity with Industry 4.0 shopfloor connectivity protocols (OPC UA, MQTT) and IoT edge device integration
  • Proven track record in managing digital transformation programs, product roadmaps, and technology implementation initiatives
  • Demonstrated ability to translate complex operational requirements into prioritized, actionable use cases and technical specifications
  • Experience with user-centered design principles and gathering/incorporating end-user feedback into solutions
  • Coordinate required inputs from internal teams and external partners (process data, layouts, equipment information, automation logic, 3D/BIM data)

Skills

  • Welcome to Holly Springs, North Carolina- home to
  • Roche/Genentech's largest-ever investment:
  • This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028.

Benefits

  • Lead use cases from intake and prioritization through simulation development, validation, implementation, and benefit realization-with a focus on shopfloor operator value
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This listing is sourced directly from Genentech's careers page and normalized into a canonical job model.