Generalproximity

Generalproximity

Scientist, Medicinal Chemistry

San Francisco, CA

Sponsorship not specifiedDetected 53 days ago
OKRsIntellectual PropertyPharmacologyFDA RegulatoryCell CultureResearchCommunication

About the role

  • We are seeking a medicinal chemist to be a member of our Chemistry/Drug Discovery Team.
  • In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.
  • Initiative, independence, and self-accountability are some of our most valued traits.

Responsibilities

  • We love people who are excited about what they are doing and are generally attempting to build a high-energy team.
  • Design, synthesis, and optimization of induced proximity medicines (e.g. PROTACs or other IPMs)
  • We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.

Requirements

  • Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
  • Medicinal chemistry optimization: SAR, PK/PD, and strong working knowledge of DMPK principles

Nice to have

  • HTS and phenotypic assay development
  • Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
  • Computational or molecular dynamics drug discovery experience
  • Experience managing synthetic chemistry CRO teams
  • Prior experience on teams that have successfully advanced research to the clinic
  • We will buy you books. 📚
  • Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer.
  • Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

Skills

  • A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets.
  • Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited.
  • The Position
  • Top-notch written and oral communication skills.

Compensation

  • Title and compensation commensurate with experience.

Benefits

  • Strong equity incentives.
  • Top tier medical, dental, and vision coverage + One Medical membership.
  • 401(k) retirement plans.
  • Education and health/fitness incentive programs.
  • Meditation retreats-do a ten-day Vipassana retreat without counting towards vacation days.

Company info

  • Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won't drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴
  • Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.
  • Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.
  • Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.
  • Title and compensation commensurate with experience.
  • Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed.
  • We look forward to hearing from you.:)
  • More info at jobs.generalproximity.bio
  • The most common mechanism of action for FDA-approved drugs is inhibition, but there are many other possible perturbation types whose potential remains unrealized.
  • General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem.
  • We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
  • Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines, and our technology holds the same promise.

Visa & Work Authorization

  • Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.
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This listing is sourced directly from Generalproximity's careers page and normalized into a canonical job model.