Serif Biomedicines, Inc.

Senior Scientist, Protein Engineering

Cambridge, MA · Senior

Sponsorship not specified$126k-$182kDetected 6 days ago

ComplianceRecruitingCRISPRMolecular BiologyNGSExperimental DesignLeadershipCommunicationCollaborationMentoring

About the role

This role reports to the Director of Molecular Biology and includes management of one direct report.

Using protein prediction models and ab initio modeling to develop proteins of novel function in silico and drive their selection and validation on wet bench
Design and build complex DNA libraries, including barcoding strategies, to enable pooled screening and variant tracking.
Help build and scale high-throughput workflows for DNA and RNA production, screening, and data analysis.
Track record of demonstration execution of large-scale library screens to support protein engineering and CAR optimization or binder identification and characterization
Contribute to plasmid and construct design for engineered proteins and cell-based systems.
Own construct QC, sequence analysis, and tracking of variants, including NGS-based workflows.
Work with external vendors as needed, balancing internal builds and outsourcing to meet timelines.
Partner closely with other teams, including CMC, to provide designs, materials, and timelines.
Mentor junior scientists and support strong practices in experimental design and data quality.
Maintain clear and reproducible records (ELN, sequence tracking, sample management).

We encourage all candidates with exemplary experience in related fields to apply.
Technical Expertise
BS with 14+ years, MS with 12+ years, or PhD with 5+ years of relevant industry experience in molecular biology, bioengineering, or a related field.
Deep expertise in protein engineering and CAR
Expert-level experience with NGS-based library analysis, variant tracking, and sequence QC.
Experience mentoring or managing junior scientists.
Excellent communication skills, with the ability to translate complex ideas across disciplines.
If you have some of the experience listed above but not all, we encourage you to apply anyway.
Experience comes in many forms, skills are transferable, and passion goes a long way.

Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information.

This listing is sourced directly from Serif Biomedicines, Inc.'s careers page and normalized into a canonical job model.