Insitro

Insitro

Senior Scientist, Cardiac Modeling

South San Francisco, CA · Senior

Sponsorship not specified$156k-$166kDetected 51 days ago
Machine LearningBioinformaticsCRISPRMicroscopyExperimental DesignLeadershipCommunicationMentoringPublic Speaking

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odds of building a lasting career here

57Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role76
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

Lottery odds assume a STEM candidate.

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Employer immigration record

from this employer's Department of Labor filings

Files H-1B transfers

1 transfer filing in the last year, covering 1 worker. Median labor-condition decision: 7 days. An employer that already files transfers is one that can take over an existing H-1B.

Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.

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About the role

  • insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients.
  • Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics-whether small molecules, biologics, or oligos.
  • With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point.

Responsibilities

  • Differentiation & QC: Lead the generation, characterization, and maintenance of iPSC lines and their differentiation into cardiomyocytes, with rigorous quality control at each stage of the pipeline
  • 2D & 3D Formats: Design, implement, and optimize iPSC-CM assays in both 2D monolayer and 3D/engineered heart tissue (EHT) formats, with a focus on scalability and data quality
  • Genetic Disease Models: Build and apply isogenic iPSC-CM disease models - including CRISPR-edited lines carrying disease-associated variants - to study cardiovascular pathophysiology
  • Functional Readouts: Develop readouts of cardiomyocyte biology relevant to disease -contractility, electrophysiology, calcium handling, stress responses - in formats compatible with high-throughput data acquisition
  • Rigor & Reproducibility: Drive documentation, SOPs, and data standards that ensure reproducible, publication-quality results across the cardiac biology platform
  • Experiment Design for ML: Partner with ML and computational biology teams to design experiments that generate high-quality training data and to interpret model outputs in biological context
  • Genetic Disease Modeling: Track record building and applying genetic iPSC-CM disease models - patient-derived lines, CRISPR-edited isogenic pairs - to study cardiovascular mechanisms
  • ML Curiosity: You're enthusiastic about working alongside ML scientists and understand how experimental design shapes what a model can learn
  • Builder Mentality: You thrive building systems from the ground up and bring the same rigor to a new workflow as to a published experiment
  • Independent & Adaptive: You drive projects forward independently in a fast-paced environment while staying aligned with team priorities

Requirements

  • Advanced Degree: Ph.D. in cell biology, biomedical engineering, cardiac physiology, or a related field, with at least 3 years of industry experience
  • High-Content Imaging: Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines
  • Cross-functional Collaborator: You work fluidly across biology, computation, and chemistry, and communicate clearly across disciplines

Compensation

  • Our target starting salary for successful US-based applicants for this role is $156,000 - $166,000.
  • To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
  • This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

Benefits

  • Excellent medical, dental, and vision coverage as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
  • We believe diversity, equity, and inclusion need to be at the foundation of our culture.
  • insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines.
  • Access to a free commuter bus network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area

Company info

  • We are seeking a Senior Scientist to join our cardiac disease biology team.

Equal opportunity

  • insitro is an equal opportunity employer.
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This listing is sourced directly from Insitro's careers page and normalized into a canonical job model.