Insitro

Senior Scientist, Cardiac Modeling

South San Francisco, CA · Senior

Sponsorship not specified$156k-$166kDetected 35 days ago

Machine LearningBioinformaticsCRISPRMicroscopyExperimental DesignLeadershipPublic Speaking

About the role

insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients.
Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics-whether small molecules, biologics, or oligos.
With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point.

Responsibilities

Differentiation & QC: Lead the generation, characterization, and maintenance of iPSC lines and their differentiation into cardiomyocytes, with rigorous quality control at each stage of the pipeline
2D & 3D Formats: Design, implement, and optimize iPSC-CM assays in both 2D monolayer and 3D/engineered heart tissue (EHT) formats, with a focus on scalability and data quality
Genetic Disease Models: Build and apply isogenic iPSC-CM disease models - including CRISPR-edited lines carrying disease-associated variants - to study cardiovascular pathophysiology
Functional Readouts: Develop readouts of cardiomyocyte biology relevant to disease -contractility, electrophysiology, calcium handling, stress responses - in formats compatible with high-throughput data acquisition
Rigor & Reproducibility: Drive documentation, SOPs, and data standards that ensure reproducible, publication-quality results across the cardiac biology platform
Experiment Design for ML: Partner with ML and computational biology teams to design experiments that generate high-quality training data and to interpret model outputs in biological context
Genetic Disease Modeling: Track record building and applying genetic iPSC-CM disease models - patient-derived lines, CRISPR-edited isogenic pairs - to study cardiovascular mechanisms
ML Curiosity: You're enthusiastic about working alongside ML scientists and understand how experimental design shapes what a model can learn
Builder Mentality: You thrive building systems from the ground up and bring the same rigor to a new workflow as to a published experiment
Independent & Adaptive: You drive projects forward independently in a fast-paced environment while staying aligned with team priorities

Requirements

Strong foundational knowledge of cardiomyocyte biology and cardiovascular disease
Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines
Advanced Degree: Ph.D. in cell biology, biomedical engineering, cardiac physiology, or a related field, with at least 3 years of industry experience
High-Content Imaging: Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines
Cross-functional Collaborator: You work fluidly across biology, computation, and chemistry, and communicate clearly across disciplines

Compensation

Our target starting salary for successful US-based applicants for this role is $156,000 - $166,000.
To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
401(k) plan with employer matching for contributions

Benefits

To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
Excellent medical, dental, and vision coverage as well as mental health and well-being support
Open, flexible vacation policy
Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
New hire stipend for home office setup
Monthly cell phone & internet stipend

Company info

We are seeking a Senior Scientist to join our cardiac disease biology team.

Equal opportunity

insitro is an equal opportunity employer.

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This listing is sourced directly from Insitro's careers page and normalized into a canonical job model.