St. Jude Children’s Research Hospital

St. Jude Children’s Research Hospital

Postdoctoral Research Fellow — Clonal Evolution and Genome Engineering in Inherited Bone Marrow Failure Disorders

Memphis, TN

Sponsorship not specifiedDetected 12 days ago
PythonData AnalysisBioinformaticsqPCRCRISPRFlow CytometryNGSCell CultureScientific WritingResearchProtein AnalysisWestern BlottingMentoring

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PERM / green-card track50
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About the role

  • A postdoctoral research associate position is available in the lab of Alyssa Kennedy.
  • The lab studies how somatic adaptation shapes disease trajectory, why certain clones are compensatory while others are pre-malignant, and whether therapeutic genome editing can shift that balance.
  • Projects span primary patient samples, iPSC cell line models, CRISPR/base-editing screens, and single-cell genomics, with direct access to a clinical bone marrow failure program.

Responsibilities

  • Jude fosters a vibrant postdoc community that supports a well-balanced life.
  • Technology may support portions of our process, but recruiting decisions involve human review and engagement.
  • A Sense of Community: St. Jude fosters a vibrant postdoc community that supports a well-balanced life. A dynamic environment promotes connections and camaraderie among postdocs from all backgrounds.

Requirements

  • Track record of productivity, including at least one first-author publication (published or in press)
  • Hands-on experience and expertise with molecular and cell biology methods: mammalian cell culture, cloning, qPCR, flow cytometry, Western blot, single cell RNA sequencing, basic biochemistry
  • Comfort with quantitative data analysis and clear scientific writing
  • Ability to work independently and collaboratively in a team environment
  • NGS analysis experience (scRNA-seq, targeted error-corrected sequencing, WES/WGS) and fluency in R or Python
  • Required:
  • PhD, MD, or MD/PhD (or expected within six months) in hematology, cancer biology, genetics, genome engineering, immunology, or a related field
  • Preferred:
  • CRISPR/Cas9 or base/prime editing experience, including guide design and editing outcome analysis
  • Primary hematopoietic stem and progenitor cell culture, CD34+ work, or prior work with xenotransplantation/murine models
  • About the Kennedy lab and St. Jude:
  • The Kennedy lab is a dedicated group of curious scientists focused on transforming the care of children with bone marrow failure and leukemia. We welcome learners and curious minds to join our team.
  • St. Jude Children's Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine's "Best Workplaces in Health Care & Biopharma" and Glassdoor's "Best Places to Work," and is located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food and culture.
  • We are in pursuit of the brightest minds in biomedical sciences, individuals poised to contribute to our research progress. Other than access to top-quality scientists and mentors, as a postdoctoral trainee at St. Jude, you will have:

Compensation

  • Embark on your journey with a competitive salary starting at $72,500 a year, comprehensive benefits and generous relocation assistance, reflecting our commitment to recognize and invest in talent.

Company info

  • We are recruiting a postdoctoral fellow to study the mechanisms of clonal evolution and leukemic transformation in inherited bone marrow failure syndromes, with a focus on Shwachman-Diamond syndrome (SDS).
  • We are in pursuit of the brightest minds in biomedical sciences, individuals poised to contribute to our research progress.
  • We are committed to a human-centered hiring experience.

Equal opportunity

  • Jude is an Equal Opportunity Employer
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