Neurocrine
Senior Scientist, Computational Chemistry
US CA San Diego · Senior
Sponsorship not specified$111k-$151kDetected 6 days ago
PythonC++Machine LearningProject ManagementFDA RegulatoryResearchCommunicationCollaborationProblem Solving
About the role
- Responsible for the communication and presentation of computationally derived results to the discovery project teams to facilitate effective decision-making & demonstrate an independent work style while being fully collaborative & team-oriented. _
- Your Contributions (include, but are not limited to):
- This is an on-site role requirement (in San Diego site)
Responsibilities
- Responsible for driving the execution of computational driven methodologies to help design optimized compounds with balanced (targets, DMPK, in-vivo) in drug discovery programs.
- Molecular Modeling applied to compound design and optimization such as Pharmacophore Analyses, Library Design, virtual HTS, Diversity/Similarity Analyses, Scaffold Hopping
- Independently driving forward Drug Discovery projects involving Structure Based Design including, but not limited to, target protein flexibility considerations
- Engages stakeholders from multiple Research functions to deliver and/or exchange key results
Requirements
- MS/MA degree in Chemistry and 3+ years of similar experience noted above OR
- Experience in one or more of the following
- Familiarity with well-known commercial molecular modeling software suites is also desirable such as Schrodinger, CCG or Open Eye
- Strong knowledge of one or more scientific disciplines, becoming expert in one discipline
- Strong knowledge of scientific principles, methods and techniques
- Ability to meet multiple deadlines, with a high degree of accuracy and efficiency
Nice to have
- BS/BA degree in Chemistry and 5+ years of relevant experience, including familiarity utilizing any or all of the following: Protein-Ligand modeling, Molecular Dynamics, Homology Modeling is preferred OR
- PhD in Computational Chemistry or related field and some relevant experience.
- Postdoctoral experience in Cheminformatics preferred
Compensation
- The annual base salary we reasonably expect to pay is $110,800.00-$151,000.00.
Benefits
- Serves as a subject matter expert in 1 or more molecular discovery approaches such as: Structure-based Design & FEP, Virtual Screening, Quantum Chemistry, Machine Learning / Modern AI etc.
Company info
- Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. ( *in collaboration with AbbVie )
- About the Role:
- Responsible for driving the execution of computational driven methodologies to help design optimized compounds with balanced (targets, DMPK, in-vivo) in drug discovery programs. Provides impactful insights and collaboration on projects ranging from early lead identification to the late-stage optimization of advanced projects. Serves as a subject matter expert in 1 or more molecular discovery approaches such as: Structure-based Design & FEP, Virtual Screening, Quantum Chemistry, Machine Learning / Modern AI etc. Responsible for the communication and presentation of computationally derived results to the discovery project teams to facilitate effective decision-making & demonstrate an independent work style while being fully collaborative & team-oriented. _
- Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs.
- We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders.
- The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas.
- For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions.
- We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science.
- For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. ( *in collaboration with AbbVie )
- to relieve suffering for people with great needs.
- Advances the company's computational platform with expert knowledge providing innovative ideas to make significant contributions, that is aligned with team's strategy to progress compounds forward for multiple projects
- Ability to work as part of a team; may train lower levels
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This listing is sourced directly from Neurocrine's careers page and normalized into a canonical job model.