Katalysthealthcareslifesciences

Scientist III

Worcester, MA, United States · Mid

Sponsorship not specifiedDetected 362 days ago
Clinical TrialsClinical ResearchqPCRCRISPRFlow CytometryPharmacovigilanceResearchProtein AnalysisAnimal StudiesCommunication

About the role

  • The candidate will work collaboratively with cross-functional and therapeutic area teams to advance company's lentiviral gene therapy pipeline.
  • The ideal candidate will have strong expertise and experience in lentivirus vector engineering, production, analytics and in vitro screening, as well as experience in managing CROs for lentiviral production.
  • All your information will be kept confidential according to EEO guidelines.

Responsibilities

  • Collaborate with cross-functional and therapeutic area teams to advance Client lentiviral vectors into pipeline.
  • Design and engineer lentiviral vectors and manage lentiviral production by leveraging internal and CRO resources.
  • Help build and establish analytical and cell-based screening assays (e.g., p24, VCN, SupT1 titration, ELISA, qPCR, ddPCR, WES, FACS, and endotoxin assay).
  • Maintain a comprehensive Electronic Lab Notebook documenting experiments.
  • Maintain a high level of productivity in the team with clear daily, detailed, and accurate documentation of experiments.
  • Perform all activities in compliance with applicable regulations, client's policies and guidelines.
  • Bring a "can do " spirit to work and deliver on other responsibilities as assigned.

Requirements

  • Ph.D. in biology or a relevant field with 5+ years of experience in lentiviral vector-based gene therapy in addition to post-doctoral experience
  • or MS with at least 10 years of relevant experience
  • Experience in managing CROs for lentiviral production.
  • Experience in analytical and screening methods for characterization of lentiviral vector products Experience in CAR-T cell therapy.
  • Ability to work effectively in a highly collaborative and dynamic environment.

Nice to have

  • Experience in in vivo lentiviral targeted delivery is a plus.

Company info

  • The Biotherapeutics and Genetic Medicine Group is seeking a highly motivated scientist for initiating the lentiviral delivery platform for gene therapy in a newly established Genetic Medicine team.
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