Flagshippioneeringinc

Scientist I, In Vitro Pharmacology

Boston, MA USA

Sponsorship not specified$100k-$127kDetected 7 days ago

ComplianceRecruitingClinical TrialsPharmacologyFlow CytometryCell CultureProtein AnalysisWestern BlottingAnimal Studies

About the role

We are looking for a highly motivated, broadly skilled cell biologist and assay developer to join our growing Pharmacology team.
Occasionally, this individual may contribute to in vivo and ex-vivo pharmacology activities to progress projects and the platform.

Design and execute cell-based and biochemical assays to assess Syntein TM activity, target engagement, and mechanism of action to drive discovery programs
With guidance from manager, conceptualize and develop novel assays for diverse target classes and disease areas
Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise
Collaborate cross-functionally to enable novel methods, assays and screening workflows, including optimization of assays for incorporation into screening funnels and cross-training of colleagues on methods
Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry & Screening teams to drive design-make-test cycles

Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
Strong proficiency in renal disease biology and preclinical kidney models is highly desirable
Industry level experience with best practices related to data records creation and maintenance and workflow integrity
Demonstrated ability to work in a fast-paced environment
PhD in molecular or cell biology or related discipline with up to 2 years relevant experience; industry experience is preferred
Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; experience with cellular/high content imaging and image analysis a plus (e.g., Incucyte, Phenix)
Experienced with primary cell culture and characterization, including tissue dissociation
Experienced in assay development and testing in model systems and human with good understanding of analytical and pre-analytical methods and solutions
Demonstrated ability to independently design, develop and optimize diverse cell-based functional assays (e.g., intracellular signaling) and interpret complex results
Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality

industry experience is preferred
experience with cellular/high content imaging and image analysis a plus (e.g., Incucyte, Phenix)
PhD in molecular or cell biology or related discipline with up to 2 years relevant experience
Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays
In vivo pharmacology experience would be a plus
Proficiency in laboratory automation and semi-automated screening workflows is a plus

Abiologics, Inc currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond.
vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality.
We are pioneering the development of Synteins™, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies.
Abiologics is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology.
Abiologics was founded in Flagship Pioneering's venture creation engine, where companies such as
At Flagship, we accept impossible missions to enable bigger leaps.

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