Revolution Medicines

Revolution Medicines

Senior Director, Clinical Pharmacology

Redwood City, California, United States · Director · Full-time

Sponsorship not specified$244k-$305kDetected 22 hours ago
CompliancePharmacologyFDA RegulatoryLeadershipCommunicationCollaboration

About the role

  • We are seeking a passionate and experienced Clinical Pharmacologist with strong early development background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.
  • As a member of the Early Development Clinical Pharmacology group, you will:
  • Provide strategic insight and technical leadership within the Clinical Pharmacology function.

Responsibilities

  • Author technical reports and/or regulatory documents for major milestones of clinical development, specifically IND, EOP1 & EOP2 Briefing Documents. Participate in regulatory interactions and responses to regulatory questions.
  • Work with the Discovery organization to support assets in the IND-enabling stage, including collaboration with DMPK and Toxicology groups in assessment of human start dose and assessment of the need for human DDI studies.
  • Design and report Clin Pharm studies such as hADME, Food-Effect and DDI studies.
  • Represent the Clinical Pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions.

Requirements

  • A Ph.D. or Pharm.D (with Fellowship) with Pharmaceutical Sciences background with 8+ years of relevant industry experience in Clinical Pharmacology.
  • Hands-on experience with WinNonlin and Clin Pharm study designs.
  • Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.

Skills

  • Prior experience with small molecules oncology drug development.
  • Familiar with FDA's Project Optimus guidance.
  • Well-informed in current and emerging standards of regulatory requirements and expectations for clinical pharmacology.
  • Strong understanding of DMPK, CMC and Toxicology and related regulatory guidance is required.
  • Prior management experience.
  • Prior experience interacting with FDA on dose optimization.
  • Hand-on experience with PBPK models.
  • #LI-Hybrid #LI-CT1
  • The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below.

Compensation

  • $244,000 - $305,000 USD
  • Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process.

Company info

  • Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers.
  • The company's R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins.
  • The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
  • As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
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This listing is sourced directly from Revolution Medicines's careers page and normalized into a canonical job model.