Genentech
Senior Scientist, Analytical Development - Stem Cell & Metabolomics
South San Francisco · Senior
Sponsorship not specified$105k-$194kDetected 4 days ago
ExcelqPCRCRISPRFlow CytometryCell CultureMass SpectrometryProtein AnalysisCommunicationProblem SolvingOrganizational Skills
About the role
- Mitochondrial Characterization: Evaluate mitochondrial function, membrane potential, dynamics (fission/fusion), biogenesis, and ROS production in stem-cell-derived models
- This role is based onsite in South San Francisco, CA.
Responsibilities
- Design and execute real-time functional metabolic assays to measure oxygen consumption rate (OCR) and extracellular acidification rate (ECAR)
- Maintain detailed laboratory notebooks, draft standard operating procedures (SOPs), and present functional metabolic data to cross-functional teams
- Cell Bioenergetic Profiling: Design and execute real-time functional metabolic assays to measure oxygen consumption rate (OCR) and extracellular acidification rate (ECAR)
- Documentation & Reporting: Maintain detailed laboratory notebooks, draft standard operating procedures (SOPs), and present functional metabolic data to cross-functional teams
- You have CMC Experience - a proven track record of developing assays within a CMC/regulatory framework (understanding phase-appropriate validation, ICH guidelines, etc.).
Requirements
- You have a PhD in Cell Biology, Biochemistry, Bioengineering, or a related field
- or a Master's in Cell Biology, Biochemistry, Bioengineering, or a related field with 3+ years of relevant academic/industry experience.
- You have demonstrated experience working at the bench.
- You have a demonstrated level of biological domain expertise in the metabolism space.
- You have a deep understanding of cellular energetics, mitochondrial function, or metabolic flux assays.
- You have a demonstrated level of expertise in stem cell biology.
- You have the ability to culture, differentiate and characterize iPSCs, MSCs, or primary cells.
- You have a PhD in Stem Cell Biology, Biochemistry, or a related field
- You have a high level of familiarity with flow cytometry, qPCR/ddPCR, ELISA, and metabolic flux analyzers (e.g., Seahorse).
- You have demonstrated strong interpersonal and communication skills with the ability to communicate technical knowledge in a clear and understandable manner, especially to non-experts
Compensation
- The expected salary range for this position based on the primary location of South San Francisco, CA is $104,700 - 194,400.
Benefits
- Relocation benefits are not being offered for this role.
Equal opportunity
- equal opportunity employer.
- If you have a disability and need an accommodation in relation to the online
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