Treeline Biosciences
Senior Scientist / Principal Scientist – Process Chemistry
San Diego, California, United States · Principal
Sponsorship not specified$166k-$190kDetected 136 days ago
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About the role
- This role centers around close collaboration with the medicinal chemistry team within the discovery portfolio.
- This role focuses on route invention, reaction development, and scalable synthesis of key intermediates and drug candidates.
- Scientific Impact - Enable drug discovery through innovative synthetic strategy.
Responsibilities
- Collaborate with medicinal chemistry partners to support candidate selection and developability assessments. Advise and assist with sourcing scaffolds and intermediates as appropriate.
- Design and execute route scouting and synthetic strategies for drug candidates and key intermediates.
- Design and optimize chemical transformations and scalable synthetic routes to enable efficient and robust processes for discovery and early development programs.
- Enable rapid compound synthesis and methodologies to support SAR campaigns and discovery timelines.
- Support multi-gram to kilogram-scale synthesis for biological and toxicology studies.
- Manage external partners and cultivate strong, collaborative relationships to support program objectives.
- Collaborate with medicinal chemistry partners to support candidate selection and developability assessments.
- Enable drug discovery through innovative synthetic strategy. Develop creative and efficient routes that accelerate SAR exploration, enable rapid evaluation of new chemical matter, and deliver material for early toxicology studies.
- Solve complex synthetic challenges. Apply modern synthetic methodologies to access structurally complex molecules and support emerging therapeutic modalities.
- Translate discovery chemistry into scalable processes. Design practical routes that support both rapid compound synthesis and early-stage scale-up.
Requirements
- Ph.D. in Organic Chemistry or related discipline with 3-8+ years of relevant industry or postdoctoral experience
- M.S. with 6-10+ years of industry experience also considered.
- Experience with complex molecule synthesis and route optimization.
- Familiarity with scale-up considerations and impurity control in chemical processes.
- Ability to work effectively within cross-functional discovery teams.
- Strong communication and collaboration skills with a proven ability to work cross-functionally in a fast-paced, science-driven environment.
- Experience with modern synthetic methodologies and technologies (e.g., catalysis, flow chemistry, photochemistry, high-throughput experimentation, as well as other techniques).
- Experience enabling synthesis of structurally complex drug candidates or emerging modalities.
- Strong expertise in synthetic organic chemistry, reaction development, and route design.
- Experience working with and managing external CDMO partners.
- Strong written and verbal communication skills.
- Strong project leadership skills with the ability to manage complex timelines, multiple stakeholders, and evolving program priorities.
- High level of personal integrity, commitment to excellence and to our patients
- Desired Experience
Compensation
- The anticipated annual base salary range for candidates who will work in San Diego is $166,380 to $189,533.
Company info
- Keep the following in mind to protect yourself: - Treeline Biosciences will never ask for money from you as part of our recruitment process.
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