Biohub
Postdoctoral Fellow, Functional Genomics
New York, NY (Onsite)
Sponsorship not specifiedDetected 14 days ago
PythonBioinformaticsCRISPRMolecular BiologyCell CultureResearchLab ResearchCommunicationCollaboration
About the role
- The role involves designing, optimizing, and validating new pooled CRISPR workflows and driving projects that provide new insights for immune system reprogramming and training foundational AI models.
- You will join a highly collaborative team at the forefront of massive-scale perturbation technologies and AI model development to predict how to reprogram the immune system to prevent, identify, and treat human disease.
- This researcher will be based at our Satellite site in NYC integrated with a team specializing in advanced functional genomics technologies, particularly massive-scale pooled CRISPR screens and single-cell profiling, to understand immune cell regulation.
Responsibilities
- Massive-scale Perturb-seq: Design, optimize, scale, and carry out large-scale Perturb-seq experiments in iPSC-derived immune cells and immortalized cell lines.
- Assay development: Design, optimize, and validate CRISPR functional genomics technologies to obtain higher quality, more complex data about cell-state regulation in human cells.
- Data generation: Partner with AI researchers to process and interpret large-scale single-cell datasets.
- Collaboration and dissemination: Collaborate across disciplines to understand systems-level reprogramming of human immune cells.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Relocation support for employees who need assistance moving
Requirements
- This is a wet lab-based, hands-on position that specifically requires experience with functional genomics method development and high-volume human cell culture.
Nice to have
- Experience with CRISPR screening in iPSCs and primary immune cells.
- Experience analyzing large-scale genomics datasets.
- Working knowledge of R or Python and single-cell analysis tools.
- Experience with cytokine or small molecule immune cell assays.
- PhD in molecular biology, systems biology, genetics, biomedical engineering, or related field
- Proven expertise and demonstrated success in large-scale functional genomics assays and method development
- Experience designing and executing pooled CRISPR screens and/or compound perturbation assays
- Excellent communication skills and proven ability to work in a collaborative team environment
Compensation
- The New York City, NY base pay range for a new hire in this role is $93,000.00.
Benefits
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Benefits for the Whole You
- To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
Company info
- Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof.
- We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease.
- Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research ev
- Our Immune Cell Reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer's, and Parkinson's.
- These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed.
- You can learn more about our work here.
- Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine.
- Pursue large scientific challenges that cannot be pursued in conventional environments
- Enable individual investigators to pursue their riskiest and most innovative ideas
- Facilitate research by scientists and clinicians at our home institutions and beyond
- We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.
This listing is sourced directly from Biohub's careers page and normalized into a canonical job model.