Biogen
Research Fellow, Chemical Biology & Proteomics
Cambridge, MA
Sponsorship not specifiedDetected 4 days ago
PharmacologyCell CultureResearchMass SpectrometryCommunication
About the role
- The Chemical Biology & Proteomics group is seeking a highly motivated Research Fellow to advance the application of chemoproteomics to drug discovery.
- Working closely with medicinal chemists, biologists, and proteomics scientists, the Fellow will contribute to innovative drug discovery programs while gaining exposure to industrial research and development.
Responsibilities
- Design and execute chemoproteomic experiments to characterize target engagement and proteome-wide selectivity of covalent small molecules in cells and tissues.
- Perform live-cell labeling experiments followed by bioorthogonal click chemistry, enrichment workflows, and mass spectrometry-based proteomic analysis.
- Establish and optimize workflows for profiling reactive and ligandable amino acid residues, including cysteine-directed chemoproteomic approaches.
- Collaborate closely with medicinal chemistry, biology, pharmacology, and computational scientists to guide compound optimization and candidate selection.
- Evaluate emerging chemoproteomic technologies and implement new methodologies to expand platform capabilities.
- Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission.
- At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve.
Requirements
- Hands-on experience with bioorthogonal chemistry, including click chemistry-based probe labeling and enrichment workflows.
- Experience performing mammalian cell culture and biochemical experiments involving small molecules and chemical probes.
- Experience preparing samples for LC-MS/MS-based proteomics and familiarity with modern quantitative proteomic workflows.
- Excellent written and verbal communication skills and ability to work effectively in multidisciplinary teams.
Nice to have
- Experience with chemoproteomic methods such as ABPP, isoTOP-ABPP, cysteinome profiling, or residue-centric proteomics.
- Familiarity with quantitative proteomics approaches including TMT, DIA, PRM, or targeted mass spectrometry.
- Experience analyzing proteomics datasets using software such as FragPipe, MaxQuant, DIA-NN, or related tools.
- Experience with affinity enrichment strategies, streptavidin-based pulldowns, and probe development.
- Knowledge of protein biochemistry, target engagement assays, and mechanism-of-action studies.
- Interest in applying chemical biology technologies to neurodegeneration and other challenging disease areas.
- Job Level: Professional
- Additional Information
Compensation
- Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Benefits
- Medical, Dental, and Vision Insurance
- Up to 15 days of paid accrued annual vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Employee stock purchase plan
- Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills.
Company info
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 401(k) program participation with company matched contributions
- We are a global team with a commitment to excellence, and a pioneering spirit.
- As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact.
This listing is sourced directly from Biogen's careers page and normalized into a canonical job model.