NewLimit
Principal/Senior Scientist, mRNA engineering
South San Francisco · Principal
Sponsorship not specified$170k-$200kDetected 11 days ago
PythonMachine LearningBioinformaticsMolecular BiologyNGSAnimal Studies
About the role
- About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan.
- We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
- This is a hands-on, lab based role focused on the synthesis, purification, and characterization of mRNA at large scales and high purities.
Responsibilities
- Implement rigorous quality control assays, including direct RNA sequencing, fragment analysis, dsRNA quantitation, and residual contaminant analysis.
- Author and maintain detailed SOPs and batch records, ensuring all production runs meet GLP standards.
- Independently design and execute experiments to improve mRNA sequence potency, specificity, and manufacturing performance.
- Train, manage, and mentor other team members on mRNA optimization and production workflows.
- We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells.
- NewLimit is seeking a scientist to drive our mRNA production and engineering efforts.
- You will serve as the technical lead for our production workflow, bridging the gap between molecular design and high quality material generation for in vivo and in vitro studies.
Requirements
- PhD in molecular biology, biochemistry, cell biology, or a related field or equivalent industry experience (5+ years).
- Deep hands-on experience with IVT and the specific challenges of scaling nucleic acid production.
- Proficiency with TFF and chromatography systems for the purification of large scale RNA batches.
- Strong experience in drafting technical reports and standardized protocols.
Nice to have
- Familiarity with Python or R for sequence analysis and secondary structure prediction.
- Understanding of how mRNA quality attributes impact Lipid Nanoparticle (LNP) formulation and delivery.
- Experience with complex plasmid design and bacterial scale-up for DNA template generation.
- Experience managing external contract manufacturing organizations (CMOs)
- 401(k) with company match
- Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience.
Compensation
- $170,000 to $200,000.
- Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience.
- Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.
Benefits
- Health, dental, and vision insurance
- Paid parental leave
- Industry-leading paid time off (PTO) - 20 days/year for all employees + holidays
- NewLimit offers generous benefits to ensure our team can focus on our mission:
- NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO.
Company info
- Execute and scale end-to-end mRNA production, including template preparation, in vitro transcription (IVT), and purification (TFF, chromatography).
- https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.
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