Twenty Twenty Therapeutics

Twenty Twenty Therapeutics

Mission Architect

Arlington, VA · Senior · Full-time

Sponsorship not specifiedDetected 111 days ago
Machine LearningLLMsPRDsCommunication

About the role

  • ABOUT THE COMPANY America is under sustained cyber attack.
  • Our adversaries infiltrate our networks, steal our IP, and degrade the digital infrastructure that modern life runs on.
  • They've learned-correctly-that those attacks rarely produce consequences.

Responsibilities

  • You will translate complex user workflows, decision points, and constraints into clear requirements and user stories that engineering can build from.
  • You will partner with the Product Manager to shape PRDs, refine scope, and ensure roadmap items reflect real user needs.
  • You will design evaluation scenarios, scoring approaches, and benchmark workflows that measure real user impact.
  • You will support customer conversations and demonstrations, translating product capabilities into language that resonates with practitioners and leadership.

Requirements

  • You are comfortable working through ambiguity and turning messy, incomplete inputs into clear direction for a team.
  • You are trusted to bring direct feedback, sound judgment, and a practical point of view to difficult trade-offs.
  • You have 7+ years of hands-on experience as a practitioner in the product's target domain, such as cyber operations, intelligence analysis, capability acquisition, or a comparable field.
  • You have strong credibility with practitioners in that domain and a track record of trusted judgment in high-stakes work.
  • You have helped shape user-facing tools, workflows, or interfaces used in real operational environments.
  • You have strong written and verbal communication skills across technical, operational, and executive audiences.
  • You have experience working cross-functionally with Product, Engineering, and related teams.
  • You have strong judgment for defining acceptance criteria and evaluating whether a feature truly meets user needs.

Nice to have

  • You have transitioned from a practitioner role into product development, requirements engineering, or capability development.
  • You have worked with AI/ML-powered products, including agentic systems, LLM-based workflows, or knowledge graph applications.
  • You have created training content, reference materials, or doctrine for operational users.
  • You might work with AI/ML-powered product experiences, including LLM-driven and agentic workflows.
  • You might work with knowledge graph applications and products built around complex data relationships.
  • You might work with evaluation tooling, scenario libraries, scoring rubrics, and acceptance benchmark frameworks.
  • You might work closely with modern product and engineering teams shipping user-facing software for operational environments.
  • Some positions may require an active U.S. Government security clearance, depending on the product's customer environment.

Benefits

  • Medical, dental, and vision plan options.
  • Life / AD&D, disability coverage options.
  • Paid parental leave for eligible full-time employees.
  • Paid holidays and flexible PTO.
  • HSA/FSA options, dependent care FSA.
  • Commuter benefits.
  • Building fitness center.
  • Desk setup stipend.
  • We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, veteran status, disability, or any other protected status.
  • Benefits vary by location, role, and eligibility.

Company info

  • America is under sustained cyber attack.
  • Twenty was founded to change that, by making our adversaries think twice before they attack us.
  • Our vision is American and allied primacy in cyberspace-a future where they cannot contest us, deterrence is assured, and the free world remains secure.
  • Founded in 2024, Twenty Technologies (www.twenty.io http://www.twenty.io) industrializes offensive cyber operations for the U.S. and its allies.
  • Headquartered in Arlington, Virginia, Twenty has raised $138M from Accel, Caffeinated Capital, Friends & Family Capital, Point72 Ventures, General Catalyst, and In-Q-Tel.
  • The Mission Architect is the senior domain expert embedded on a product team to ensure what gets built matches how users actually work.
  • You will turn real operational workflows, constraints, and edge cases into clear product requirements, testable acceptance criteria, and high-fidelity user experiences.
  • You will partner closely with Product Managers, engineers, designers, and researchers to keep product decisions grounded in reality.
  • This role is for someone who has deep credibility in their field and wants to shape software that materially improves outcomes for practitioners.

Equal opportunity

  • equal opportunity employer.
  • If you need a reasonable accommodation during the hiring process, let us know and we will work with you.

Visa & Work Authorization

  • Government security clearance, depending on the product's customer environment
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This listing is sourced directly from Twenty Twenty Therapeutics's careers page and normalized into a canonical job model.