Exel
Executive Director, Toxicology
Alameda, CA · Director
Stay score
odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$5,472 more — $290,472 — moves this role to Level IV and 4 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $290,472 would place this position at wage Level IV. That figure is within the posted range, and I'd like to target it. This role classifies under "Natural Sciences Managers" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Natural Sciences Managers (11-9121) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
Employer immigration record
from this employer's Department of Labor filings
Files H-1B transfers
Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
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About the role
- The base pay range for this position is $285,000 - $405,500 annually.
- The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location.
- The base pay offered will take into account the candidate's geographic region, job-related knowledge, skills, experience and internal equity, among other factors.
Responsibilities
- Lead Toxicology strategy for small molecule and biotherapeutic programs from discovery through registration.
- Define integrated nonclinical safety, safety pharmacology, toxicokinetic, pharmacokinetic, and drug metabolism strategies that support candidate selection, IND-enabling activities, clinical development, and global regulatory submissions.
- Oversee the design, conduct, monitoring, interpretation and reporting of GLP and non-GLP toxicology, safety pharmacology and investigative toxicology studies conducted internally or through CROs.
- Represent Toxicology on project teams, governance forums, regulatory meetings and development partner interactions; communicate scientific rationale, risk assessments and recommendations to senior leadership.
- Author, review and defend nonclinical pharmacology, toxicology and safety sections of regulatory documents, including pre-IND packages, INDs, CTAs, IBs, NDAs, BLAs and global marketing applications.
- Partner with Discovery, Clinical Pharmacology, Translational Sciences, Pathology, Regulatory Affairs, Clinical Development, CMC, Quality Assurance, CROs, and external collaborators to drive integrated development plans and risk-based decision-making.
- Manage CRO and external partner relationships to ensure study quality, compliance, timelines, budgets, data integrity and timely delivery of nonclinical outputs.
- Identify and resolve nonclinical safety issues that may affect program progression; develop de-risking strategies and recommendations based on scientific, regulatory and portfolio considerations.
- Develop resource plans, budget forecasts, organizational capabilities and scalable processes to support current and future portfolio needs.
- Drive external scientific visibility through appropriate publications, presentations, partnerships and participation in relevant scientific forums.
Requirements
- It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
- Identifies resources and capabilities required to support current and future portfolio needs
- PhD in Toxicology, Pharmacology, Pathology, DVM or related discipline and a minimum of 15 years of relevant experience
- Comprehensive knowledge of nonclinical safety assessment, toxicology, safety pharmacology, DMPK, GLP regulations, global regulatory expectations and drug development from discovery through registration.
Skills
- PhD in Toxicology, Pharmacology, Pathology, DVM or related discipline and a minimum of 15 years of relevant experience; or,
- Equivalent combination of education and experience.
- DABT or equivalent board certification preferred.
- Experience supporting discovery, IND-enabling, clinical development, and global regulatory submission activities.
- Advanced leadership, communication, collaboration, analytical, problem-solving, decision-making and influencing skills.
- 10% Travel may be required, up to 10% of the time
- Knowledge, Skills and Abilities
Compensation
- The base pay range for this position is $285,000 - $405,500 annually.
- The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location.
Benefits
- Establish and maintain the vision, strategy, scientific standards and operating model for the Toxicology function to support organizational objectives and portfolio growth.
This listing is sourced directly from Exel's careers page and normalized into a canonical job model.