St. Jude Children’s Research Hospital

St. Jude Children’s Research Hospital

Cell Assay Lead/Principal Scientist - Blue Sky Kinases

Memphis, TN · Principal

Sponsorship not specified$138k-$262kDetected 4 days ago
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Cap-exempt (no lottery)100
Sponsors year-round100
Entry-level history60
PERM / green-card track50
Fits your clock70

Files H-1B any time — no cap, no lottery. The 2026 weighted-selection rule doesn't touch it, which makes this the strongest structural path for entry-level talent. Pay is often lower, but your odds of staying are dramatically higher.

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States it is exempt from the H-1B cap

In 14 Department of Labor filings, this employer states it is a nonprofit or governmental research organization — one of the statutory grounds for exemption from the H-1B cap. Cap-exempt employers can file year-round without entering the lottery.Employer's own attestation on a Department of Labor wage determination, not a USCIS determination — exemption is decided per petition.

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About the role

  • Jude Children's Research Hospital in Memphis, TN.
  • The candidate will guide junior staff in designing high-quality cell biology experiments, critically review the experimental data generated by the cell biology team, and assist with troubleshooting.
  • The Blue Sky Initiative "Seeing the Invisible in Protein Kinases" is an interdisciplinary project in The Department of Structural Biology and is supported by US $50 million in institutional funding.

Responsibilities

  • Develop strategies and plans for implementing a wide spectrum of cell-based assays to assess processes either regulated by or regulating kinases, including but not limited to evaluation of protein phosphorylation, protein interaction, protein localization, RNA abundance (qRT-PCR), protein ubiquitination, and protein abundance
  • Lead and collaborate with a team of scientists on multiple structure-guided cell biology projects, and provide project direction and guidance to junior staff.
  • Work closely with the cell biology team to implement and troubleshoot a variety of cell-based phenotypic assays, including but not limited to viability, apoptosis, autophagy, migration, or differentiation
  • Perform cell assay data analyses, including statistical analysis using graphing software or R scripts
  • Technology may support portions of our process, but recruiting decisions involve human review and engagement.
  • Extraordinary support

Requirements

  • Fifteen (15) years of relevant work experience is required with a Bachelor's degree.
  • Thirteen (13) years of relevant work experience is required with a Master's degree.
  • Ten (10) years or relevant work experience is required with a PhD.

Nice to have

  • Experience in analysis of protein kinases and phosphorylation-dependent signaling events or pathways
  • Expertise in culturing a variety of types of cells, such as cancer cell lines, primary cells, mouse embryo fibroblasts, inducible human pluripotent cells, immune cells, neuronal cells, and muscle cells
  • Expertise in multiple methods for exogenous protein expression
  • Proficiency in presentation of experimental design and results using PowerPoint or similar software
  • Experience with mouse models, preferred but not essential
  • Cloning, PCR, and qRT-PCR
  • Sterile technique
  • Cell transfection, transduction, or infection to exogenously express proteins of interest transiently or for cell line generation

Compensation

  • In recognition of certain U.S. state and municipal pay transparency laws, St.
  • Jude is including a reasonable estimate of the compensation range for this role.
  • It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case.
  • A reasonable estimate of the current salary range is $138,320 - $262,080 per year for the role of Cell Assay Lead/Principal Scientist - Blue Sky Kinases.
  • This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs.

Benefits

  • Hardworking, well-organized, flexible, and capable of multitasking efficiently in a fast-paced environment
  • Explore our exceptional benefits!

Company info

  • We are looking for an experienced cell biologist to participate in our exciting studies of the human protein kinome.
  • This Senior Scientist position is part of the Blue Sky Initiative " Seeing the Invisible in Protein Kinases " at St.
  • We are committed to a human-centered hiring experience.

Equal opportunity

  • Jude is an Equal Opportunity Employer
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This listing is sourced directly from St. Jude Children’s Research Hospital's careers page and normalized into a canonical job model.