Superluminalrx

Superluminalrx

Scientist-Principal Scientist, Protein Design & Structure

Boston, MA · Principal

Sponsorship not specifiedDetected 50 days ago
ExpressMachine LearningPharmacologyMolecular BiologyResearchProtein AnalysisLeadershipCommunicationCollaboration

About the role

  • This role involves hands-on laboratory work and scientific leadership.

Responsibilities

  • Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression.
  • Expression & Purification: Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
  • Cross-Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization.
  • evaluate and implement new technologies.
  • Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings.
  • Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies.
  • The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs.
  • Design, execute, and optimize constructs for GPCR expression.
  • Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
  • Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization.

Requirements

  • Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience
  • or a master's or bachelor's degree in a related field with commensurate industry experience.
  • Deep knowledge of GPCR biology and membrane protein structure-function relationships.
  • Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC).

Nice to have

  • Experience with structural biology methods (data collection and processing for Cryo-EM).
  • Experience in laboratory automation in protein sciences & purification.

Compensation

  • Superluminal offers a comprehensive benefits package that fully covers employees' annual deductibles and monthly premiums for medical, dental, and vision insurance.

Benefits

  • Superluminal offers a comprehensive benefits package that fully covers employees' annual deductibles and monthly premiums for medical, dental, and vision insurance.
  • The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance.

Company info

  • We are seeking a highly innovative and experienced Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering and production efforts.
  • We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation.

Equal opportunity

  • Statement:
  • Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race
  • religion
  • national origin
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