Legend Biotech US

VP, Head of Preclinical Development

Somerset, New Jersey, United States · Vp · Full-time

No sponsorship$294k-$387kDetected 17 hours ago

PharmacologyCRISPRExperimental DesignAnimal StudiesLeadershipCollaboration

About the role

We are seeking an exceptional scientist-leader to serve as Vice President, Head of Preclinical Development.
This is a senior, externally visible leadership role accountable for the full preclinical development program across in vitro pharmacology, in vivo pharmacology, and toxicology for all pipeline compounds globally.

Serve as the internal scientific authority on in vitro pharmacology, in vivo pharmacology, and toxicology - setting methodological standards, experimental design principles, and data interpretation frameworks.
Lead preclinical science for novel modalities including lentiviral vector-based in vivo CAR-T, ex vivo cell therapies, and gene-modified immune cell platforms, with deep understanding of the unique preclinical characterization requirements of each
Own the preclinical component of IND applications, accountable for integrated pharmacology and toxicology summaries, study tabulations, and the Written Summary of nonclinical pharmacology and toxicology.
Build, lead, and develop a high-performing Preclinical Development team comprising in vitro pharmacology scientists, in vivo pharmacology scientists, and toxicologists - both internal staff and embedded CRO personnel.
Mentor and develop team members at all levels
create individual development plans, provide regular performance feedback, and support career progression.
Mentor and develop team members at all levels; create individual development plans, provide regular performance feedback, and support career progression.

Minimum 15 years of progressive experience in preclinical drug development, with at least 5 years in a senior leadership role with direct accountability for IND-enabling programs.
Deep expertise in at least two of the three core functions (in vitro pharmacology, in vivo pharmacology, toxicology), with working knowledge of the third.
Experience in cell therapy, gene therapy, or advanced therapy development.
Track record of successful IND submissions with clear accountability for the nonclinical pharmacology and toxicology sections.
Experience managing CRO relationships for outsourced preclinical and GLP studies, including vendor qualification, protocol development, monitoring, and report review.
Applicants must be authorized to work in the United States.
If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law.

Performance-based bonus and/or equity is available to employees in eligible roles.
Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one.
Please note: These benefits are offered exclusively to permanent full-time employees.
Contractors are not eligible for benefits through Legend Biotech.

Legend Biotech is a clinical-stage biotech company developing cell therapies for hematological malignancies, solid tumors and autoimmune diseases.

This listing is sourced directly from Legend Biotech US's careers page and normalized into a canonical job model.