Oxford BioTherapeutics
Scientist (Multi-specific Antibody Development)
San Jose, California
Sponsorship not specifiedDetected 31 days ago
FirewallCRISPRFlow CytometryProtein AnalysisAnimal StudiesLeadershipCommunicationCollaborationPublic Speaking
About the role
- Oxford Biotherapeutics is a clinical-stage biotechnology company focusing on the development of antibody therapeutics for the treatment of cancer.
- OGAP is used to identify novel, highly tumor specific antigens for novel first-in-class ADC, T-cell Engager (TCE) and Chimeric Antigen Receptor (CAR-T) targets.
- Our clinical and pre-clinical pipeline of novel biologics is balanced between internal programs, focused on ADCs and checkpoint regulators, and externally partnered programs with key innovators in oncology such as Roche, GSK and Zymeworks.
Requirements
- Experience supporting the discovery, characterization, and optimization of T-cell engagers, bispecific antibodies or other immune redirecting biologics.
- Combines a humble, team‑oriented mindset with the ability to form and voice clear, independent viewpoints.
- This role combines deep hands-on experimental expertise with scientific leadership, assay innovation, and cross-functional collaboration to advance OBT's multi-specific pipeline.
- Assay Development & Technical Expertise
Nice to have
- Experience managing cross-functional/CRO studies related to in vivo cancer models
- Track record of scientific impact demonstrated through publications, patents, presentations, or program advancement.
Skills
- Experience with stable cell line generation (Lentiviral transduction, CRISPR KO)
- Expertise with antibody binding assays (ELISA, flow cytometry)
- Immune cell co-culture cytotoxicity assays with live readouts (Incucyte, eSight)
- Multiparameter flow cytometry and panel design
- T-cell activation assays (Reporter assays, immune-profiling and cytokine secretion)
- Strong written and verbal communication skills, with the ability to present data to multidisciplinary audiences.
- Scientist Level
- PhD with 1-3 years of relevant post‑PhD experience, or
- MS with 5-7 years of relevant industry experience in immunology, cell biology, or biologics discovery
- Preferred Qualifications and
- Experience with affinity tuning/detuning and epitope selection to achieve logic-gated targeting
- Hands on experience with complex co-culture systems (e.g., organoids)
Compensation
- 5 sick days per year
Benefits
- Medical, dental and vision insurance for employee and dependents
- FSA (Flexible Spending Account)
- 120 hours of Paid Time Off
- Employee Referral Bonus Program
- One of our top priorities is to maintain the health and wellbeing of our employees and their families.
- To achieve this goal, we offer comprehensive benefits
- Annual bonus program
- New hire stock options
Company info
- OBT's OGAP-verify® platform is the world's largest, cancer specific, membrane protein library, directly measuring plasma membrane protein expression in patient tumors.
- Our lead asset, OBT076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development.
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This listing is sourced directly from Oxford BioTherapeutics's careers page and normalized into a canonical job model.