Nurix Therapeutics
Director, Nonclinical Toxicology Operations
Brisbane, California, United States · Director
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About the role
- The role will be responsible for operations activities including owning timelines, budgets, contracts, and cross-functional coordination for a portfolio of targeted protein degradation programs.
- You will thrive here if you are highly organized, scientifically fluent, comfortable holding teams and stakeholders to a schedule, and energized by turning complex, interdependent work into clear milestones and decisions.
Responsibilities
- Toxicology study support and vendor management
- Partner with Toxicology Leads and Study Directors to scope, design, and schedule GLP and non-GLP in vivo and in vitro safety studies, including exploratory tox, DRF, GLP repeat-dose toxicology, safety pharmacology, and genetic toxicology.
- Identify, qualify, and manage CROs and specialty vendors
- Own the contract lifecycle: draft and route work orders, MSAs, change orders, and amendments
- reconcile invoices and support accruals and forecasting.
- Build and maintain integrated study timelines
- Coordinate protocol and report review cycles, ensuring documents move efficiently through internal review, QA, and sign-off.
- Program management, late lead optimization to IND
- Serve as project manager for assigned discovery and development programs from late lead optimization through candidate selection, IND-enabling studies, and IND filing.
Requirements
- Required: M.S. or Ph.D. in a life sciences discipline (toxicology, pharmacology, biology, chemistry, pharmaceutical sciences, or related).
- Track deliverables required for regulatory submissions, including study reports, certificates of analysis, and test article documentation.
- Education
- Preferred: formal project management credential such as PMP.
- Experience
- Skills and attributes
- Proficiency with project management tools and methods, including integrated timelines, critical path analysis, and resource planning (e.g., MS Project, Smartsheet, Planisware, or equivalent). Familiarity with AI tools a plus.
Nice to have
- Typically, 10+ years of relevant biotech or pharmaceutical experience, including demonstrable project management ownership of multidisciplinary programs.
- Track record managing CROs and external vendors, including contracting, budget tracking, and performance management.
- Direct experience supporting and coordinating IND-enabling activities
- Working knowledge of small molecule drug discovery and development, nonclinical safety assessment, and GLP requirements, with scientific fluency sufficient to plan, question, and integrate the work.
- Experience in targeted protein degradation, oncology, or immunology is an advantage.
- Proficiency with project management tools and methods, including integrated timelines, critical path analysis, and resource planning (e.g., MS Project, Smartsheet, Planisware, or equivalent).
- Familiarity with AI tools a plus.
- Clear, concise written and verbal communication
Skills
- Exceptional organizational skills and attention to detail, with the judgment to know what matters and what does not.
- Clear, concise written and verbal communication; able to present status and risk to senior leadership without embellishment.
- Comfort with ambiguity and shifting priorities in a fast-moving discovery environment.
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
- Act as a connective hub across functions and sites, resolving interface issues before they become timeline issues.
- Contribute to continuous improvement of project management practices, templates, and tools within the group.
Compensation
- $220,700 - $252,667
This listing is sourced directly from Nurix Therapeutics's careers page and normalized into a canonical job model.