Simons Foundation
Senior Software Engineer, Genomics
162 Fifth Avenue, New York, NY · Senior · Full-time
Stay score
odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$5,589 more — $165,589 — moves this role to Level III and 3 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $165,589 would place this position at wage Level III. That figure is within the posted range, and I'd like to target it. This role classifies under "Software Developers" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Software Developers (15-1252) · New York-Newark-Jersey City, NY-NJ. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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About the role
- This is a high-impact role that directly advances the study of human genomics and disease.
- This is a hands-on backend role for an experienced engineer with expertise in biological data, genomics, and -omics technologies.
- They will also have experience processing large-scale -omics datasets, maintaining production software systems, designing and optimizing data-intensive pipelines, and supporting machine learning workflows in scientific computing environments.
Responsibilities
- Contribute to the design, architecture, and implementation of new HumanBase features and major infrastructure improvements
- Design, develop, and optimize scalable genomics and biomedical data processing pipelines that ingest, normalize, and transform heterogeneous datasets
- Collaborate closely with computational biologists, data scientists, and external partners to align engineering efforts with scientific and platform goals
- Contribute to operational support, maintenance, and continuous improvement of production systems supporting HumanBase
- The Center for Computational Biology (CCB) is seeking an experienced senior software engineer to join a growing team of developers within CCB and the other centers across the Flatiron Institute who help build and maintain HumanBase.
- The successful candidate will collaborate closely with researchers at the Center for Computational Biology to translate cutting-edge computational biology research into scalable production systems and data pipelines that power HumanBase.
Requirements
- At least 8 years of professional software engineering experience, including work on production systems and data-intensive applications
- Extensive experience with Python, including development of complex data pipelines and use of applicable software libraries
- Strong experience with relational databases such as PostgreSQL or MySQL, including schema design and query optimization
- Experience with containerization and cloud-native infrastructure technologies such as Docker and Kubernetes
- Demonstrated experience with the full software development lifecycle (SDLC), including testing, CI/CD, version control, and deployment
- Excellent communication skills, with the ability to engage technical and non-technical audiences, including senior leadership.
- Strong cross-functional collaboration skills, with a track record of working effectively with non-engineering stakeholders to translate needs into software solutions.
- Perform other duties or tasks as assigned or required
Nice to have
- Advanced degree in Computer Science, Engineering, Bioinformatics, or a related field.
- Expertise in bioinformatics, including experience with genomic data processing, analysis pipelines, and related computational methods.
- Familiarity with AWS or other major cloud platforms.
- Experience with high-performance computing (HPC) environments.
- Please submit a résumé and cover letter stating your interest in the position.
- Our Commitment to Expanding Pathways to Science & Opportunities for All:
- Many of the greatest ideas and discoveries come from a diverse mix of minds, backgrounds, and experiences.
- Experience working with large, heterogeneous biological datasets in Python (HDF5, Parquet, PyArrow, xarray ) -ideally in genomics or biomedical contexts
Skills
- Related Skills & Other Requirements
Compensation
- The full-time annual compensation range for this position is $ 160,000-$200,000 depending on experience.
Benefits
- In addition to competitive salaries, the Simons Foundation provides employees with an outstanding benefits package.
- Integrate machine learning and statistical methods into production workflows for analysis of complex biological datasets
This listing is sourced directly from Simons Foundation's careers page and normalized into a canonical job model.