Elevatebio
Scientist II, LNP, Process Development & Manufacturing
Waltham, Massachusetts, United States · Mid
Sponsorship not specified$125k-$165kDetected 23 days ago
StatisticsProcess ImprovementGMPMass Spectrometry
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odds of building a lasting career here
54Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70
Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.
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About the role
- Characterize LNP and tLNP formulations using analytical techniques to evaluate size, PDI, encapsulation efficiency, lipid quantification, ligand density, conjugation efficiency, and formulation stability.
- Analyze and interpret experimental data, identify process improvement opportunities, and communicate technical findings, project updates, and recommendations to internal stakeholders and external clients.
- We are seeking a highly skilled LNP Scientist to join our process development team at ElevateBio.
Responsibilities
- Execute LNP production to support process characterization, technology transfer, and manufacturing readiness for LNP-based drug products.
- Work closely with cross-functional teams, including MSAT, AD, Quality, Manufacturing, and external clients, to support process development, scale-up and technology transfers.
Requirements
- Minimum of 3 years working with LNP-based products in a process development or manufacturing setting.
- Experience Requirements
- Familiarity with GMP regulations, regulatory expectations, and preparation of technical documentation supporting CMC activities, technology transfer, and regulatory filings for LNP-based formulated products.
- Proven record of manufacturing LNP-based products through either process development work or tech transfer activities.
- Ability to analyze and interpret data linking receptor engagement, ligand density, nanoparticle, cellular uptake, and delivery performance to guide tLNP optimization.
- Experience operating automated LNP manufacturing and process development systems (e.g., PNI/Cytiva, Knauer) and filtration systems, including tangential flow filtration (TFF) platforms (e.g., Repligen).
Nice to have
- Experience with targeted LNP development, including ligand conjugation strategies, functionalization approaches, and characterization of targeted delivery systems.
- Working knowledge of mRNA process development unit operations including in-vitro transcription (IVT), chromatography (Affinity, RP, IEX), and integration with LNP formulation processes.
- Proficiency with statistical analysis software (e.g., JMP) and experience applying Design of Experiments (DoE) approaches and data-driven approaches to LNP formulation and process development.
- The budgeted range for this position is $125,000 - $165,000.
- ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Compensation
- This range is a good faith estimate of the expected salary range for this position, based on a wide range of factors including qualifications, experience and training, operational and business needs and other considerations permitted by law
Company info
- The Role: We are seeking a highly skilled LNP Scientist to join our process development team at ElevateBio.
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