Prime Medicine

Prime Medicine

Informatics Engineer

Cambridge, MA · Senior · Full-time

Sponsorship not specified$134k-$163kDetected 29 days ago
PythonCode ReviewGitPostgreSQLAWSCloud PlatformsDockerTerraformCI/CDPlatform EngineeringData EngineeringLLMsRAGAgentic AILangGraphAI OrchestrationLogisticsBioinformaticsCRISPRNGSResearchLab ResearchGxP

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odds of building a lasting career here

54Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.

Lottery odds assume a STEM candidate.

Personalize to your clock →

H-1B wage level

the lottery is wage-weighted — each level is one more entry

Level I · 1×
Level I$114,2751 entry
Level II$138,2372 entries
Level III$162,1983 entries
Level IV$186,1604 entries

$4,237 more — $138,237 — moves this role to Level II and 2 lottery entries. That figure is inside the range the employer already advertised.

Based on the DOL prevailing wage for this occupation and worksite, a base salary of $138,237 would place this position at wage Level II. That figure is within the posted range, and I'd like to target it. This role classifies under "Software Developers" for prevailing-wage purposes.

DOL prevailing wage, 2026-27 wage year · Software Developers (15-1252) · Boston-Cambridge-Newton, MA-NH. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.

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About the role

  • You will work in close partnership with our computational biology team and our cloud infrastructure team.
  • Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients.
  • Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung.

Responsibilities

  • Design and build the data platform connecting NGS instruments, laboratory informatics systems (Benchling), and AWS cloud compute
  • Build production-grade APIs, SDKs, and internal tools that bring genomic data and analytical capabilities to scientists across the organization.
  • Build the orchestration layer for the automated, event-triggered execution of our scientific pipelines. The pipelines themselves (amplicon-seq, off-target analysis, and others) are co-developed with our computational biology team
  • you'll own how they run, scale, and integrate.
  • Build integrations across the scientific tool chain so data moves reliably between ELNs, LIMS, instrument software, and cloud compute.
  • Partner with computational biologists, lab scientists, and our cloud-support team to continuously improve platform performance, cost, and reliability.
  • Design and build the data platform connecting NGS instruments, laboratory informatics systems (Benchling), and AWS cloud compute; covering automated ingestion, provenance tracking, scalable storage, and observability.
  • Build the orchestration layer for the automated, event-triggered execution of our scientific pipelines.
  • The pipelines themselves (amplicon-seq, off-target analysis, and others) are co-developed with our computational biology team; you'll own how they run, scale, and integrate.

Requirements

  • 5+ years of full-time engineering experience (3+ for those with an MS or PhD) in production environments.
  • Production AWS experience with depth in event-driven, cloud-native architectures, including AWS Lambda, EventBridge (or comparable event-routing infrastructure), and Infrastructure as Code with Terraform or CDK.
  • Experience in a life-science related industry involving scientific or regulated data, such as biotech, pharma, healthtech, clinical informatics, scientific instrumentation, or agricultural genomics.
  • US work authorization at the time of application is required.
  • Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

Nice to have

  • Knowledge of NGS technology, workflows and pipeline architecture is strongly preferred.
  • Hands-on workflow orchestration experience.
  • Familiarity with Nextflow/NextFlow Tower/Seqera Platform preferred.
  • Laboratory informatics experience with Benchling or comparable ELN/LIMS, as an operator, builder, or administrator.
  • AI / LLM tooling and agentic systems (LangChain, LangGraph, MCPs, RAG architectures).
  • Gene editing familiarity: CRISPR, base editing, prime editing.
  • GxP / 21 CFR Part 11 / regulated-software experience.
  • Plotly Dash, Streamlit, Spotfire, Retool, or similar tools for internal apps and data visualizations.

Compensation

  • $134,000 - $163,000 USD

Benefits

  • Competitive base salary, equity, and standard benefits.
  • Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education.
  • This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Company info

  • A Python coding exercise is part of the process Logistics and policy - Hybrid with office in Cambridge, MA.
  • We are not currently able to sponsor visas.
  • What we're looking for
  • This is an Infrastructure engineering focused role, well suited to candidates whose primary background is software engineering, data engineering, or scientific platform engineering, with a strong interest in applying those skills to scientific problems.
  • We're hiring an Informatics Engineer to build the scientific data and computing platform that powers Prime Medicine's gene editing programs.
  • A Python coding exercise is part of the process

Equal opportunity

  • Prime Medicine is proud to be an equal opportunity employer.

Visa & Work Authorization

  • US work authorization at the time of application is required.
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This listing is sourced directly from Prime Medicine's careers page and normalized into a canonical job model.