Glyphic Biotechnologies

Staff / Senior Scientist, Assay Development (Chemistry)

Berkeley, CA · Staff+ · Full-time

Sponsorship not specified$123k-$188kDetected 60 days ago

Experimental DesignMass SpectrometryCommunicationProblem SolvingAdaptability

About the role

This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.
This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.
We celebrate diversity and are committed to creating an inclusive environment for all employees.

Optimize bioconjugation methods for peptide loading into the expansion assay
establish robust, high-efficiency loading protocols that perform reliably across diverse peptide populations and physicochemical characteristics.
Identify, characterize, and optimize peptide labeling during the ProSE sequencing assay, leveraging mechanistic understanding of Edman chemistry and amino acid side-chain reactivity and stability.
Develop reagents and methods to maximize the stability of peptides, DNA, and peptide-DNA chimeras throughout the ProSE sequencing assay.
Partner with the Chemistry team to develop amino acid side-chain protection chemistries.
Design and determine the order of operations for chemical manipulations within the assay workflow - including decisions on when specific steps occur on-bead versus off-bead, and how side-chain protection and deprotection strategies are sequenced relative to assay cycles - to ensure compatibility, efficiency, and analytical interpretability.
Optimize selective cleavage chemistry workflows for use within the sequencing assay.
Optimize for efficiency, selectivity, and compatibility with assay conditions.
Develop stabilization strategies for sensitive assay intermediates and conjugates.
Optimize bioconjugation methods for peptide loading into the expansion assay; establish robust, high-efficiency loading protocols that perform reliably across diverse peptide populations and physicochemical characteristics.

Advanced degree in organic chemistry, chemical biology, biochemistry, or a related field
Industry experience designing multi-step chemical workflows in complex biological systems, including sequencing or determining the order of chemical manipulations across assay conditions.
MS/PhD with 6+/4+ years of experience (for Senior Scientist)
MS/PhD with 8+/6+ years of experience (for Staff Scientist)
Proficiency with analytical characterization of complex conjugates and assay intermediates: HPLC (RP and IEX), LC-MS/MS, UV-Vis
Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds.
Ability to thrive in a fast-paced environment with evolving priorities.

Familiarity with nanopore or single-molecule sequencing chemistry, and the demands it places on assay reagent purity, stability, and uniformity.
Experience with solid-phase peptide synthesis (SPPS), including on-resin modification, selective sidechain deprotection, and non-standard protecting group strategies.
Prior experience in an early-stage biotech or tools/diagnostics company.
Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
Treats obstacles as problems to be creatively solved, not reasons something can't be done.
Shares early and directly when assumptions change, results are unclear, or timelines are at risk.
What you can expect from this role

Learn from a diverse team of world-class scientists and engineers
Contribute to first-of-their kind technologies, high-impact publications, and patents

Estimated Base Salary $123,000 - $187,575
This is the pay range for this position that we reasonably expect to pay.
Individual compensation is based on various factors including, experience, education, skillset, and geographic location.

Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

This listing is sourced directly from Glyphic Biotechnologies's careers page and normalized into a canonical job model.