Generalproximity

Principal Scientist, Cancer Biology

San Francisco, CA · Principal

Sponsorship not specifiedDetected 179 days ago

FDA RegulatoryCRISPRFlow CytometryMolecular BiologyScientific WritingResearchExperimental DesignAnimal StudiesAnimal ModelsLeadershipCommunication

About the role

Initiative, independence, and self-accountability are some of our most valued traits.
We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.
PhD in Cancer Biology, Cell Biology, or related field.

In this position, you will help lead and manage our Biology Team and work closely with our Platform Team in the development of our core drug discovery technology.
We love people who are excited about what they are doing and are generally attempting to build a high-energy team.
Animal models of cancer (GEMM, orthotopic, xenograft models), in vivo study design, and PK/PD interpretation

Experience navigating IND-enabling studies and working on teams that have successfully advanced research to the clinic
Experience working at the interface of cancer biology and chemistry <span data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335551550"

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets.
Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited.
The Position
Exceptional leadership, interpersonal, and communication skills, with a track record of managing high-performing, multidisciplinary teams.

The most common mechanism of action for FDA-approved drugs is inhibition, but there are many other possible perturbation types whose potential remains unrealized.
General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem.
We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines, and our technology holds the same promise.
We are seeking an experienced cancer biologist to help lead our Biology Team.
We are here to create life-saving medicines for the patients who need it most.

Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

This listing is sourced directly from Generalproximity's careers page and normalized into a canonical job model.