Profluent

Profluent

Associate Director - Director, In Vivo Pharmacology

Emeryville, California, United States; On-site · Director

Work authorization required$200k-$260kDetected 30 days ago
SparkLogisticsPharmacologyBioinformaticsqPCRCRISPRMolecular BiologyNGSExperimental DesignAnimal StudiesLeadershipCommunicationPublic Speaking

About the role

  • You will generate and interpret decision-quality in vivo datasets that guide editor selection, dose strategy, candidate nomination, and IND-enabling development plans.
  • Sponsorship will not be provided now or at any time in the future for this position.
  • Hiring Salary Range $200,000 - $260,000 USD

Responsibilities

  • Lead in vivo pharmacology strategy for Profluent's customized base editor programs, spanning rodent and NHP studies from early proof-of-concept through candidate nomination and IND-enabling planning.
  • Design and oversee studies evaluating editing efficiency, delivery performance, tissue biodistribution, exposure, dose response, durability, pharmacodynamic biomarkers, tolerability, and translational relevance
  • Lead and manage external study execution with CROs and vivarium partners, including protocol development, vivarium operations, vendor selection, study monitoring, sample logistics, data QC, troubleshooting, and report review
  • Partner with bioanalytical, molecular biology, computational, and translational teams (or CROs) to integrate NGS, ddPCR/qPCR, RNA/protein, histology, clinical chemistry, cytokine, immunology, and other study readouts
  • Build scalable in vivo pharmacology capabilities, including study design templates, decision criteria, CRO/vendor workflows, sample management processes, and data review standards
  • Contribute to regulatory-facing pharmacology packages, including summaries of study design, dose selection, biodistribution, pharmacodynamics, durability, and translational rationale
  • Profluent is an AI-first protein design company.
  • Profluent is seeking a rigorous and highly collaborative Associate Director - Director to lead in vivo pharmacology strategy and execution for our customized base editor therapeutics.
  • You will oversee rodent and non-human primate (NHP) studies designed to evaluate editing activity, delivery, biodistribution, durability, tolerability, biomarker response, and translational potential.
  • The successful candidate will serve as the in vivo pharmacology lead on cross-functional program teams, partnering closely with gene editing, protein engineering, delivery, computational biology, bioanalytics, translational science, and external CROs.

Requirements

  • PhD or equivalent in pharmacology, physiology, molecular biology, genetics, bioengineering, or a related field, + 6-8 years of relevant industry experience in in vivo pharmacology and preclinical development
  • Experience with genetic medicines, such as genome editing, base editing, gene therapy, RNA medicines, oligonucleotide therapeutics, LNP delivery, viral vectors, or related modalities
  • Strong understanding of PK/PD, dose response, biodistribution, target engagement, pharmacodynamic biomarkers, translational endpoints, and preclinical development strategy
  • Ability to operate as a senior cross-functional scientific leader, translating in vivo data into program recommendations
  • Demonstrated experience designing, managing, and interpreting rodent and NHP pharmacology studies and supporting IND-enabling studies
  • Experience leading CRO studies, including protocol design, vendor oversight, study monitoring, data QC, troubleshooting, and report review
  • Excellent communication skills and experience presenting strategy, data, risks, and recommendations to program teams and senior leadership
  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Compensation

  • Hiring Salary Range $200,000 - $260,000 USD

Company info

  • Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine.
  • Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.

Equal opportunity

  • equal opportunity employer promoting diversity and inclusion in the workspace.

Visa & Work Authorization

  • Applicants must have ongoing work authorization in the United States that does not require employer sponsorship.
  • Sponsorship will not be provided now or at any time in the future for this position.
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